Matišić, Mateja; Gredičak, Matija (2021) Enantioselective construction of a tetrasubstituted stereocenter in isoindolinones via an organocatalyzed reaction between ketones and 3-hydroxyisoindolinones. Chemical Communications, 57 . pp. 13546-13547. ISSN 0022-4936
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Abstract
In a reaction catalyzed by a chiral phosphoric acid, ketones and in situ generated ketimines afford isoindolinone derivatives with a tetrasubstituted stereogenic center in high yields, and high diastereo- and enantioselectivities. An efficient enantioselective reaction between ketones and 3-hydroxyisoindolinones is described. In a reaction catalyzed by a chiral phosphoric acid, a broad range of ketones and in situ generated ketimines afforded isoindolinone derivatives comprising a tetrasubstituted stereocenter in high yields and enantioselectivities. The developed methodology is also suitable for the construction of compounds with vicinal stereogenic centers.
Item Type: | Article | ||||||||
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Uncontrolled Keywords: | Enantioselective synthesis ; Organocatalysis ; Isoindolinones ; Ketones | ||||||||
Subjects: | NATURAL SCIENCES > Chemistry > Organic Chemistry | ||||||||
Divisions: | Division of Organic Chemistry and Biochemistry | ||||||||
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Depositing User: | Matija Gredičak | ||||||||
Date Deposited: | 18 Jan 2022 11:09 | ||||||||
URI: | http://fulir.irb.hr/id/eprint/6876 | ||||||||
DOI: | 10.1039/d1cc05761h |
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