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Effects of α-Melanocortin Enantiomers on Acetaminophen-Induced Hepatotoxicity in CBA Mice

Turčić, Petra; Bradamante, Mirna; Houra, Karlo; Štambuk, Nikola; Kelava, Tomislav; Konjevoda, Paško; Kazazić, Saša; Vikić-Topić, Dražen; Pokrić, Biserka (2009) Effects of α-Melanocortin Enantiomers on Acetaminophen-Induced Hepatotoxicity in CBA Mice. Molecules, 14 (12). pp. 5017-5026. ISSN 1420-3049

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Proteins and peptides in mammals are based exclusively on L-amino acids. Recent investigations show that D-amino acids exhibit physiological effects in vivo, despite of their very small quantities. We have investigated the hepatoprotective effects of the L and D-enantiomers of α-melanocortin peptide (α-MSH). The results showed that peptide enantiomerism is related to the protective effects of melanocortin peptides in vivo. L-α-MSH exhibited potent hepatoprotective effect in the experimental model of acetaminophen induced hepatotoxicity in male CBA mice, while its D-mirror image was inefficient. Furthermore, the antibody to the L-peptide did not recognize the D-structure. The results indicate that the opposite peptide configuration may be used to modulate its function and metabolism in vivo and in vitro.

Item Type: Article
Uncontrolled Keywords: enantiomer ; α-MSH ; hepatoprotection ; hepatotoxicity ; antibody ; CD spectroscopy
Subjects: NATURAL SCIENCES > Chemistry
Divisions: Division of Molecular Medicine
Division of Physical Chemistry
NMR Center
Project titleProject leaderProject codeProject type
Maligni epidermalni kožni tumori u Hrvatskoj-Jasna Lipozenčić218-0000000-3657MZOS
Spektroskopija, kemijska svojstva i reakcije biološki aktivnih molekula-Branka Kovač098-0982915-2945MZOS
Modeliranje bioaktivnih molekula i ispitivanje njihovih svojstava i učinka-Nikola Štambuk098-0982929-2524MZOS
Depositing User: Nikola Štambuk
Date Deposited: 06 Mar 2020 09:58
DOI: 10.3390/molecules14125017

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