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Taxonomy proposal for Old World monkey adenoviruses: characterisation of several non-human, non-ape primate adenovirus lineages

Pantó, Laura; Podgorski, Iva I.; Jánoska, Máté; Márkó, Orsolya; Harrach, Balázs (2015) Taxonomy proposal for Old World monkey adenoviruses: characterisation of several non-human, non-ape primate adenovirus lineages. Archives of Virology, 160 (12). pp. 3165-3177. ISSN 0304-8608

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A species classification regarding Old World monkey adenoviruses is proposed. We determined the nucleotide sequences of PCR-amplified fragments from the genes of the IVa2, DNA-dependent DNA polymerase, penton base, and hexon proteins from every simian adenovirus (SAdV) serotype that originated from Old World monkeys for which the full genome sequence had not yet been published. We confirmed that the majority of Old Word monkey SAdVs belong to two previously established species. Interestingly, one is the most recently established human AdV species, Human mastadenovirus G, which includes a single human virus, HAdV-52, as well as SAdV-1, -2, -7, -11, -12, and -15. The other approved species, Simian mastadenovirus A includes SAdV-3, -4, -6, -9, -10, -14, and -48. Several SAdVs (SAdV-5, -8, -49, -50) together with baboon AdV-1 and rhesus monkey AdV strains A1139, A1163, A1173, A1258, A1285, A1296, A1312, A1327 and A1335 have been proposed to be classified into an additional species, Simian mastadenovirus B. Another proposed species, Simian mastadenovirus C has been described for SAdV-19, baboon AdV-2/4 and -3. Our study revealed the existence of four additional AdV lineages. The corresponding new candidate species are Simian mastadenovirus D (for SAdV-13), Simian mastadenovirus E (for SAdV-16), Simian mastadenovirus F (for SAdV-17 and -18), and Simian mastadenovirus G (for SAdV-20). Several biological and genomic properties, such as the host origin, haemagglutination profile, number of fibre genes, and G+C content of the genome, strongly support this classification. Three SAdV strains originating from the American Type Culture Collection turned out to be mixtures of at least two virus types, either of the same species (SAdV-12 and -15 types from Human mastadenovirus G) or of two different species (SAdV-5 types from Simian mastadenovirus B and Human mastadenovirus G).

Item Type: Article
Additional Information: We would like to thank Andor Doszpoly for kindly providing the PCR primers he designed for the penton base gene of SAdVs. Thanks are also due to Alistair Kidd and Alexander Zakhartchouk for generously sharing some samples with us. The research project was supported by the Hungarian Scientific Research Fund Grant OTKA NN107632 and EU Grant Advance FP7-290002.
Uncontrolled Keywords: Old World Monkey; Full Genome Sequence; Prototype Strain; Hexon; Olive Baboon
Subjects: NATURAL SCIENCES > Biology > Microbiology
NATURAL SCIENCES > Biology > Genetics, Evolution and Phylogenetics
Divisions: Division of Molecular Medicine
Depositing User: Iva Škrinjar
Date Deposited: 19 Nov 2019 13:23
DOI: 10.1007/s00705-015-2575-z

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