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Clusters of male and female Alzheimer's disease patients in the Alzheimer's Disease Neuroimaging Initiative (ADNI) database

Gamberger, Dragan; Zenko, Bernard; Mitelpunkt, Alexis; Shachar, Netta; Lavrac, Nada (2016) Clusters of male and female Alzheimer's disease patients in the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. Brain Informatics, 3 (3). pp. 169-179. ISSN 2198-4018

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Abstract

This paper presents homogeneous clusters of patients, identified in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) data population of 317 females and 342 males, described by a total of 243 biological and clinical descriptors. Clustering was performed with a novel methodology, which supports identification of patient subpopulations that are homogeneous regarding both clinical and biological descriptors. Properties of the constructed clusters clearly demonstrate the differences between female and male Alzheimer’s disease patient groups. The major difference is the existence of two male subpopulations with unexpected values of intracerebral and whole brain volumes.

Item Type: Article
Uncontrolled Keywords: Alzheimer’s disease ; Clustering ; Female and male subpopulations
Subjects: TECHNICAL SCIENCES > Computing
BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Electronics
Projects:
Project titleProject leaderProject codeProject type
Postupci strojnog učenja za dubinsku analizu složenih struktura podataka-DescriptiveInductionDragan GambergerIP-2013-11-9623HRZZ
Depositing User: Dragan Gamberger
Date Deposited: 05 Apr 2018 15:44
Last Modified: 05 Apr 2018 15:44
URI: http://fulir.irb.hr/id/eprint/4008
DOI: 10.1007/s40708-016-0035-5

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