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Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer

Andrišić, Luka; Dudzik, Danuta; Barbas, Coral; Milković, Lidija; Grune, Tilman; Žarković, Neven (2018) Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer. Redox Biology, 14 . pp. 47-58. ISSN 2213-2317

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Association of oxidative stress with carcinogenesis is well known, but not understood well, as is pathophysiology of oxidative stress generated during different types of anti-cancer treatments. Moreover, recent findings indicate that cancer associated lipid peroxidation might eventually help defending adjacent nonmalignant cells from cancer invasion. Therefore, untargeted metabolomics studies designed for advanced translational and clinical studies are needed to understand the existing paradoxes in oncology, including those related to controversial usage of antioxidants aiming to prevent or treat cancer. In this short review we have tried to put emphasis on the importance of pathophysiology of oxidative stress and lipid peroxidation in cancer development in relation to metabolic adaptation of particular types of cancer allowing us to conclude that adaptation to oxidative stress is one of the main driving forces of cancer pathophysiology. With the help of metabolomics many novel findings are being achieved thus encouraging further scientific breakthroughs. Combined with targeted qualitative and quantitative methods, especially immunochemistry, further research might reveal bio-signatures of individual patients and respective malignant diseases, leading to individualized treatment approach, according to the concepts of modern integrative medicine.

Item Type: Article
Uncontrolled Keywords: Carcinogenesis, Cancer, Oxidative stress, Lipid peroxidation, 4-hydroxynonenal, Glutathione, Metabolomics, Immunochemistry, Biomarkers, Omics science
Subjects: BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences
BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences > Oncology
Divisions: Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Lipidi, slobodni radikali i njihovi glasnici u integrativnoj onkologiji-Neven ZARKOVIC098-0982464-2519MZOS
Depositing User: Lidija Milković
Date Deposited: 19 Jan 2018 10:03
DOI: 10.1016/j.redox.2017.08.009

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