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Phylostratigraphic Profiles in Zebrafish Uncover Chordate Origins of the Vertebrate Brain

Šestak, Martin Sebastijan; Domazet-Lošo, Tomislav (2015) Phylostratigraphic Profiles in Zebrafish Uncover Chordate Origins of the Vertebrate Brain. Molecular Biology and Evolution, 32 (2). pp. 299-312. ISSN 0737-4038

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Abstract

An elaborated tripartite brain is considered one of the important innovations of vertebrates. Other extant chordate groups have a more basic brain organization. For instance, cephalochordates possess a relatively simple brain possibly homologous to the vertebrate forebrain and hindbrain, whereas tunicates display the tripartite organization, but without the specialized brain centers. The difference in anatomical complexity is even more pronounced if one compares chordates with other deuterostomes that have only a diffuse nerve net or alternatively a rather simple central nervous system. To gain a new perspective on the evolutionary roots of the complex vertebrate brain, we made here a phylostratigraphic analysis of gene expression patterns in the developing zebrafish (Danio rerio). The recovered adaptive landscape revealed three important periods in the evolutionary history of the zebrafish brain. The oldest period corresponds to preadaptive events in the first metazoans and the emergence of the nervous system at the metazoan–eumetazoan transition. The origin of chordates marks the next phase, where we found the overall strongest adaptive imprint in almost all analyzed brain regions. This finding supports the idea that the vertebrate brain evolved independently of the brains within the protostome lineage. Finally, at the origin of vertebrates we detected a pronounced signal coming from the dorsal telencephalon, in agreement with classical theories that consider this part of the cerebrum a genuine vertebrate innovation. Taken together, these results reveal a stepwise adaptive history of the vertebrate brain where most of its extant organization was already present in the chordate ancestor.

Item Type: Article
Additional Information: This article is Open Access This work was supported by the City of Zagreb and Adris Foundation grants to T.D.L. Computational resources were provided by the Croatian Society for Theoretical and Mathematical Biology (CSTMB).
Uncontrolled Keywords: brain evolution; vertebrates; phylostratigraphy; zebrafish; gene expression; development
Subjects: NATURAL SCIENCES > Biology > Genetics, Evolution and Phylogenetics
Divisions: Division of Molecular Biology
Depositing User: dr. sc. Martin Sebastijan Šestak
Date Deposited: 01 Dec 2016 11:40
Last Modified: 01 Dec 2016 15:13
URI: http://fulir.irb.hr/id/eprint/3157
DOI: 10.1093/molbev/msu319

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