Beta-HPV types in patients with head and neck pathology and in healthy subjects

Sabol, Ivan; Smahelova, Jana; Klozar, Jan; Mravak-Stipetić, Marinka; Gheit, Tarik; Tommasino, Massimo; Grce, Magdalena; Tachezy, Ruth (2016) Beta-HPV types in patients with head and neck pathology and in healthy subjects. Journal of Clinical Virology, 82 . pp. 159-165. ISSN 1386-6532

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Abstract

Background Human papillomaviruses (HPV) are a heterogeneous group of viruses classified into five genera. The beta-HPV type (beta-PV) infection is very common but mostly asymptomatic in immunocompetent individuals. However, beta-PVs play a role in Epidermodysplasia verruciformis and possibly in non-melanoma skin cancer. Head and neck cancer (HNC) is a common cancer type worldwide and high-risk alpha-PV involvement in HNC has been extensively studied but beta-PV types have rarely been the focus of such studies. Objectives To evaluate the prevalence of beta-PV types in HNC, subjects with non-malignant or potentially pre-malignant oral lesions, and healthy controls. Study design The frequency of different beta-PVs in samples from oral (n = 35) and oropharyngeal (n = 35) cancer patients, gender- and age-matched healthy controls (n = 70), and subjects with various non-malignant or potentially pre-malignant oral lesions (n = 102) was assessed by a highly sensitive, bead-based, multiplex genotyping assay. Results Overall, 54.8% of all tested samples contained at least one beta-PV type. Even though the correlation between types found in lavage and tissue specimens from cancer patients was low, there was a large statistically significant difference between oropharyngeal cancer patients and matched controls for HPV5 (P = 0.003 ; OR = 15.58) and between both oral (P = 0.026 ; OR = 5.7) and oropharyngeal cancer patients (P = 0.002 ; OR = 25.5) and controls for HPV122. In addition, there was no correlation between the prevalence of alpha and beta-PVs in the study patients. Conclusion The study provides new data on the prevalence of beta-PVs in HNC. HPV5 was found significantly associated with HNC as already observed by other studies. Additionally, the significant association of HPV122 with HNC might warrant further study as this type has not been extensively studied so far

Item Type:	Article
Uncontrolled Keywords:	Oral; Oropharyngeal; Lesion; Cancer; beta-HPV; alpha-HPV
Subjects:	BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences
Divisions:	Division of Molecular Medicine
Projects:	Project title Project leader Project code Project type Epigenetičke promjene karcinoma pločastih stanica glave i vrata-EpiC-HNSCC Magdalena Grce IP-11-2013-4758 HRZZ
Depositing User:	Ivan Sabol
Date Deposited:	16 Nov 2016 16:02
URI:	http://fulir.irb.hr/id/eprint/3122
DOI:	10.1016/j.jcv.2016.07.019

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