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Update on the core and developing cerebrospinal fluid biomarkers for Alzheimer disease

Babić, Mirjana; Švob Štrac, Dubravka; Mueck Šeler, Dorotea; Pivac, Nela; Stanić, Gabrijela; Hof, Patrick R.; Šimić, Goran (2014) Update on the core and developing cerebrospinal fluid biomarkers for Alzheimer disease. Croatian Medical Journal, 55 (4). pp. 347-365. ISSN 0353-9504

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Alzheimer disease (AD) is a complex neurodegenerative disorder, whose prevalence will dramatically rise by 2050. Despite numerous clinical trials investigating this disease, there is still no effective treatment. Many trials showed negative or inconclusive results, possibly because they recruited only patients with severe disease, who had not undergone disease- modifying therapies in preclinical stages of AD before severe degeneration occurred. Detection of AD in asymptomatic at risk individuals (and a few presymptomatic individuals who carry an autosomal dominant monogenic AD mutation) remains impractical in many of clinical situations and is possible only with reliable biomarkers. In addition to early diagnosis of AD, biomarkers should serve for monitoring disease progression and response to therapy. To date, the most promising biomarkers are cerebrospinal fluid (CSF) and neuroimaging biomarkers. Core CSF biomarkers (amyloid β1-42, total tau, and phosphorylated tau) showed a high diagnostic accuracy but were still unreliable for preclinical detection of AD. Hence, there is an urgent need for detection and validation of novel CSF biomarkers that would enable early diagnosis of AD in asymptomatic individuals. This article reviews recent research advances on biomarkers for AD, focusing mainly on the CSF biomarkers. In addition to core CSF biomarkers, the potential usefulness of novel CSF biomarkers is discussed.

Item Type: Article
Uncontrolled Keywords: Alzheimer's disease; biomarkers; cerebrospinal fluid; early diagnosis
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences
Divisions: Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Otkrivanje i praćenje bioloških biljega radi rane terapijske intervencije u Alzheimerovoj bolestiGoran ŠimićIS-09/16HRZZ
Stres, GABA-A receptori i mehanizmi djelovanja neuropsihofarmakaDubravka Švob Štrac098-0000000-2448MZOS
Farmakogenomika i proteomika serotoninskog i kateholaminskog sustavaDorotea Muck-Šeler098-0982522-2457MZOS
Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećajaNela Pivac098-0982522-2455MZOS
Fosforilacija tau proteina u razvitku i Alzheimerovoj bolestiGoran Šimić108-1081870-1942MZOS
Depositing User: Dorotea Mueck Šeler
Date Deposited: 21 Jul 2016 11:19
DOI: 10.3325/cmj.2014.55.347

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