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Antitumor mechanisms of amino acid hydroxyurea derivatives in the metastatic colon cancer model

Šaban, Nina; Stepanić, Višnja; Vučinić, Srđan; Horvatić, Anita; Cindrić, Mario; Perković, Ivana; Zorc, Branka; Oršolić, Nada; Mintas, Mladen; Pavelić, Krešimir; Kraljević Pavelić, Sandra (2013) Antitumor mechanisms of amino acid hydroxyurea derivatives in the metastatic colon cancer model. International Journal of Molecular Sciences, 14 (12). pp. 23654-23671. ISSN 1661-6596

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Abstract

The paper presents a detailed study of the biological effects of two amino acid hydroxyurea derivatives – that showed selective antiproliferative effects in vitro on the growth of human tumor cell line SW620. Tested compounds induced cell cycle perturbations and apoptosis. Proteins were identified by proteomics analyses using two-dimensional gel electrophoresis coupled to mass spectrometry, which provided a complete insight into the most probable mechanism of action on the protein level. Molecular targets for tested compounds were analyzed by cheminformatics tools. Zinc-dependent histone deacetylases were identified as potential targets responsible for the observed antiproliferative effect.

Item Type: Article
Uncontrolled Keywords: colorectal cancer; amino acid hydroxyurea derivatives; HDAC inhibition; anti-proliferative effect
Subjects: NATURAL SCIENCES > Chemistry
NATURAL SCIENCES > Biology
BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Molecular Medicine
Projects:
Project titleProject leaderProject codeProject type
Imunoadjuvantno i zaštitno djelovanje propolisa u životinjaVesna Benković119-0532265-1254MZOS
Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjekaJasna Peter-Katalinić335-0000000-3532MZOS
Molekularna obilježja miofibroblasta Dupuytrenove bolestiKrešimir Pavelić335-0982464-2393MZOS
Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvariBranka Zorc006-0000000-3216MZOS
Epigenetičke i imunomodulatorne promjene u zloćudnim tumorima glave i vrataKoraljka Gall-Trošelj098-0982464-2511MZOS
Kemoprevencija rasta tumora polifenolnim sastavnicamaNada Oršolić119-0000000-1255MZOS
Depositing User: Višnja StepaniÄ�
Date Deposited: 15 Jul 2016 09:07
Last Modified: 15 Jul 2016 09:07
URI: http://fulir.irb.hr/id/eprint/2944
DOI: 10.3390/ijms141223654

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