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Come-back of phenanthridine and phenanthridinium derivatives in 21st century

Tumir, Lidija-Marija; Radić Stojković, Marijana; Piantanida, Ivo (2014) Come-back of phenanthridine and phenanthridinium derivatives in 21st century. Beilstein Journal of Organic Chemistry, 10 . pp. 2930-2954. ISSN 1860-5397

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Abstract

Phenanthridine derivatives are one of the most intensively studied families of biologically active compounds with efficient DNA binding ; attracting attention about time of DNA structure discovery (1960ies), early recognized as a symbol of DNA intercalative binding, for many decades applied as gold-standard DNA- and RNA-fluorescent markers (ethidium bromide), probes for cell viability (propidium iodide), but also “ill-famed” for various toxic (genotoxic) and mutagenic effects. After two decades of low interest, the discovery of phenanthridine alkaloids and new studies of antiparasitic/antitumour properties of phenanthridine derivatives resulted in the strong increase of the scientific interest about the turn of this century. Here are summarized phenanthridine-related advances in the 21st century (2000-present period) with emphasis on the supramolecular interactions and bioorganic chemistry, as well as novel or improved synthetic approaches.

Item Type: Article
Uncontrolled Keywords: phenanthridine; phenanthridinium; organic synthesis; ds-DNA and ds-RNA binding; intercalation; minor groove binding
Subjects: NATURAL SCIENCES > Chemistry
Divisions: Division of Organic Chemistry and Biochemistry
Projects:
Project titleProject leaderProject codeProject type
Design, synthesis and interactions of small molecules with DNA, RNA and proteins (Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima)Ivo Piantanida098-0982914-2918MZOS
Depositing User: Lidija-Marija Tumir
Date Deposited: 25 Apr 2016 10:02
Last Modified: 25 Apr 2016 10:02
URI: http://fulir.irb.hr/id/eprint/2760
DOI: 10.3762/bjoc.10.312

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