Tumir, Lidija-Marija; Radić Stojković, Marijana; Piantanida, Ivo
(2014)
Come-back of phenanthridine and phenanthridinium derivatives in 21st century.
Beilstein Journal of Organic Chemistry, 10
.
pp. 2930-2954.
ISSN 1860-5397
Abstract
Phenanthridine derivatives are one of the most intensively studied families of biologically active compounds with efficient DNA binding ; attracting attention about time of DNA structure discovery (1960ies), early recognized as a symbol of DNA intercalative binding, for many decades applied as gold-standard DNA- and RNA-fluorescent markers (ethidium bromide), probes for cell viability (propidium iodide), but also “ill-famed” for various toxic (genotoxic) and mutagenic effects. After two decades of low interest, the discovery of phenanthridine alkaloids and new studies of antiparasitic/antitumour properties of phenanthridine derivatives resulted in the strong increase of the scientific interest about the turn of this century. Here are summarized phenanthridine-related advances in the 21st century (2000-present period) with emphasis on the supramolecular interactions and bioorganic chemistry, as well as novel or improved synthetic approaches.
| Item Type: |
Article
|
| Uncontrolled Keywords: |
phenanthridine; phenanthridinium; organic synthesis; ds-DNA and ds-RNA binding; intercalation; minor groove binding |
| Subjects: |
NATURAL SCIENCES > Chemistry |
| Divisions: |
Division of Organic Chemistry and Biochemistry |
| Projects: |
| Project title | Project leader | Project code | Project type |
|---|
| Design, synthesis and interactions of small molecules with DNA, RNA and proteins (Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima) | Ivo Piantanida | 098-0982914-2918 | MZOS |
|
| Depositing User: |
Lidija-Marija Tumir
|
| Date Deposited: |
25 Apr 2016 10:02 |
| URI: |
http://fulir.irb.hr/id/eprint/2760 |
| DOI: |
10.3762/bjoc.10.312 |
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2760
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