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Possible role of bacterial and viral infections in miscarriages

Matovina, Mihaela; Husnjak, Koraljka; Milutin Gašperov, Nina; Ciglar, Srećko; Grce, Magdalena (2004) Possible role of bacterial and viral infections in miscarriages. Fertility and Sterility, 81 (3). pp. 662-669. ISSN 0015-0282

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Abstract

To determine the role of infections in miscarriages. Chorionic villi from aborted material were subjected to cytogenetic evaluation and analyzed for the presence of Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma hominis, human cytomegalovirus (HCMV), adeno-associated virus (AAV), and human papillomaviruses (HPV). Retrospective study. University hospital and academic research institution. Karyotyping and detection of bacterial and viral DNA by means of polymerase chain reaction (PCR) in placenta specimens. In 54 (50%) of 108 samples the karyotype was normal, in 38 (35%) samples it was abnormal, and in 16 (15%) samples karyotype was undetermined. No U. urealyticum, M. hominis, HCMV, or AAV-2 DNA was detected, while C. trachomatis DNA was detected in one (1%) and HPV DNA in eight (7%) samples. No significant correlation of HPV-positive findings with karyotype status was established. Our findings do not support a role of C. trachomatis, U. urealyticum, M. hominis, HCMV, or AAV infections in miscarriages during the first trimester of pregnancy. However, further investigation should be made to determine a possible involvement of HPVs in the development of genetic abnormalities of the fetus and in miscarriages.

Item Type: Article
Uncontrolled Keywords: miscarriage ; karyotyping ; placenta ; PCR ; bacterial infections ; viral infections
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Molecular Medicine
Projects:
Project titleProject leaderProject codeProject type
Istraživanje uzroka, prevencija i liječenje infertilitetaSrećko Ciglar0044008UNSPECIFIED
Molekularno-genetički i prognostički čimbenici u nastanku raka vrata materniceMagdalena Grce0098104UNSPECIFIED
Određivanje globalnog genskog profila tumora metodom DNA-čipovaŠime Spaventi0101023UNSPECIFIED
Depositing User: Nina Milutin Gašperov
Date Deposited: 25 Nov 2015 09:54
Last Modified: 25 Nov 2015 12:31
URI: http://fulir.irb.hr/id/eprint/2279

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