Kelecic, Dina Ljubas; Karas, Irena; Lelas, Antonela; Desnica, Lana; Vukic, Tamara; Sabol, Ivan; Bender, Darija Vranesic; Kunovic, Ana; Sabic, Marina; Seiwerth, Ranka Serventi; Durakovic, Nadira; Cepo, Dubravka Vitali; Vrhovac, Radovan; Pavletic, Steven; Pulanic, Drazen; Krznaric, Zeljko (2026) Effect of vitamin D replacement on nutritional status and muscle strength in patients after allogeneic stem cell transplantation and chronic graft-versus-host disease. Clinical Nutrition ESPEN, 73 . ISSN 2405-4577
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Abstract
Purpose: Following allogeneic hematopoietic stem cell transplantation (allo-HSCT), patients may experience alterations in vitamin D status, muscle strength, and nutritional status. This prospective cohort study investigated the effect of vitamin D replacement therapy on the nutritional status and muscle strength of allo-HSCT patients, as well as its relationship with chronic graft-versus-host disease (cGVHD) characteristics. Methods: Vitamin D levels, nutritional status, and muscle strength were assessed in 65 cGVHD and 37 non-cGVHD patients before and after vitamin D replacement therapy, which was prescribed based on serum 25-hydroxyvitamin D [25(OH)D] levels. Results: Malnutrition was observed in approximately 40 %, low muscle strength in approximately 50 %, and vitamin D deficiency or insufficiency in roughly 50 % and 30 % of patients, respectively, regardless of cGVHD status. A strong correlation between nutritional status and muscle strength was found (P < 0.0005). Gastrointestinal cGVHD was identified as a risk factor for malnutrition. Both malnutrition and the severity of cGVHD were independent risk factors for low handgrip strength (HGS). Myeloablative conditioning was identified as an independent risk factor for vitamin D deficiency. Low vitamin D levels were associated with liver cGVHD (P < 0.05). Increase in serum vitamin D after vitamin D replacement was more significant in patients with vitamin D deficiency. No association between serum vitamin D levels and nutritional status or muscle strength was observed. Conclusions: The results indicate that allo-HSCT patients exhibit impaired nutritional status, low muscle strength, and vitamin D deficiency. Although vitamin D replacement therapy improved serum vitamin D levels, no association was observed with changes in nutritional status or muscle strength.
| Item Type: | Article | ||||||||
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| Uncontrolled Keywords: | vitamin D; cGVHD; nutritional status; muscle strength | ||||||||
| Subjects: | BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences > Internal Medicine | ||||||||
| Divisions: | Division of Molecular Medicine | ||||||||
| Projects: |
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| Depositing User: | Ivan Sabol | ||||||||
| Date Deposited: | 10 Apr 2026 05:38 | ||||||||
| URI: | http://fulir.irb.hr/id/eprint/11625 | ||||||||
| DOI: | 10.1016/j.clnesp.2026.102986 |
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