Supramolecular intermediates in thermo-mechanochemical direct amidations

Stolar, Tomislav; Alić Stolar, Jasna; Talajić, Gregor; Cindro, Nikola; Rubčić, Mirta; Molčanov, Krešimir; Užarević, Krunoslav; Hernández, José G. (2023) Supramolecular intermediates in thermo-mechanochemical direct amidations. Chemical Communications, 59 (90). pp. 13490-13493. ISSN 1359-7345

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Sažetak

We present a solvent-free thermo-mechanochemical approach for the direct coupling of carboxylic acids and amines, which avoids activators and additives. Detailed analysis of the reactions by ex situ and in situ monitoring methods led to the observation, isolation, and characterisation of multicomponent crystalline intermediates that precede the formation of amides. We applied our methodology for the quantitative synthesis of the active pharmaceutical ingredient moclobemide.

Vrsta građe:	Rad objavljen u časopisu
Ključne riječi:	mechanochemistry; moclobemide; intermediates; pharmaceutical;
Područja:	PRIRODNE ZNANOSTI > Kemija > Organska kemija PRIRODNE ZNANOSTI > Kemija > Primijenjena kemija
Zavodi:	Zavod za fizičku kemiju
Projekti:	Naziv projekta Voditelj projekta Šifra projekta Vrsta projekta Važnost mehanokemijske reaktivnosti u prebiotičkoj kemijskoj evoluciji i njezin prijenos na održivu kemijsku proizvodnju s niskim emisijama-PREBIOMECHEM Krunoslav Užarević IP-2020-02-4702 HRZZ In situ monitoring of mechanochemical cocrystal formation by synchrotron XRD Tomislav Stolar I-20220019 EC Internal DESY
Pohranio:	Krunoslav Užarević
Datum pohrane:	21 Feb 2024 09:36
URI:	http://fulir.irb.hr/id/eprint/8612
DOI:	10.1039/D3CC04448C

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