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The Impact of Resveratrol and Melatonin on the Genome and Oxidative Status in Ageing Rats

Gerić, Marko; Nanić, Lucia; Micek, Vedran; Novak Jovanović, Ivana; Gajski, Goran; Rašić, Dubravka; Orct, Tatjana; Ljubojević, Marija; Karaica, Dean; Jurasović, Jasna; Vrhovac Madunić, Ivana; Peraica, Maja; Sabolić, Ivan; de Andrade, Vanessa Moraes; Breljak, Davorka; Rubelj, Ivica (2025) The Impact of Resveratrol and Melatonin on the Genome and Oxidative Status in Ageing Rats. Nutrients, 17 (7). ISSN 2072-6643

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Abstract

Background: Given the growing challenges posed by an ageing population, particularly in Western countries, we aimed to investigate the potential geroprotective effects of resveratrol and melatonin in ageing rats. Methods: The animals were treated with these two compounds starting at 3 months of age and continuing until 1 year or 2 years of age. Using a multibiomarker approach, we assessed DNA damage, telomere length, and the oxidative status in their urine, liver, and kidneys. Results: Despite employing this experimental approach, our results did not provide conclusive evidence of geroprotective effects across the evaluated organs. However, we observed sex-dependent differences in response to treatment. Conclusions: Given the high potency of these two compounds, further research is warranted to explore their incorporation into daily routines as a strategy to mitigate ageing-related effects.

Item Type: Article
Uncontrolled Keywords: ageing; resveratrol; melatonin; telomeres; oxidative stress; DNA damage
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Molecular Biology
Projects:
Project titleProject leaderProject codeProject type
Starosno-ovisna ekspresija membranskih prijenosnika u štakora-AGEMETARIvan SabolićIP-2013-11-1481HRZZ
Istraživačko-edukacijski centar za zdravstvenu i medicinsku ekologiju i zaštitu od zračenja – Rekonstrukcija i dogradnja Instituta za medicinska istraživanja i medicinu rada u Zagrebu-Ana Lucić VrdoljakKK.01.1.1.02.0007EK
Depositing User: Lorena Palameta
Date Deposited: 29 Jul 2025 08:00
URI: http://fulir.irb.hr/id/eprint/9918
DOI: 10.3390/nu17071187

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