Gerić, Marko; Nanić, Lucia; Micek, Vedran; Novak Jovanović, Ivana; Gajski, Goran; Rašić, Dubravka; Orct, Tatjana; Ljubojević, Marija; Karaica, Dean; Jurasović, Jasna; Vrhovac Madunić, Ivana; Peraica, Maja; Sabolić, Ivan; de Andrade, Vanessa Moraes; Breljak, Davorka; Rubelj, Ivica (2025) The Impact of Resveratrol and Melatonin on the Genome and Oxidative Status in Ageing Rats. Nutrients, 17 (7). ISSN 2072-6643
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Abstract
Background: Given the growing challenges posed by an ageing population, particularly in Western countries, we aimed to investigate the potential geroprotective effects of resveratrol and melatonin in ageing rats. Methods: The animals were treated with these two compounds starting at 3 months of age and continuing until 1 year or 2 years of age. Using a multibiomarker approach, we assessed DNA damage, telomere length, and the oxidative status in their urine, liver, and kidneys. Results: Despite employing this experimental approach, our results did not provide conclusive evidence of geroprotective effects across the evaluated organs. However, we observed sex-dependent differences in response to treatment. Conclusions: Given the high potency of these two compounds, further research is warranted to explore their incorporation into daily routines as a strategy to mitigate ageing-related effects.
Item Type: | Article | ||||||||||||
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Uncontrolled Keywords: | ageing; resveratrol; melatonin; telomeres; oxidative stress; DNA damage | ||||||||||||
Subjects: | BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences | ||||||||||||
Divisions: | Division of Molecular Biology | ||||||||||||
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Depositing User: | Lorena Palameta | ||||||||||||
Date Deposited: | 29 Jul 2025 08:00 | ||||||||||||
URI: | http://fulir.irb.hr/id/eprint/9918 | ||||||||||||
DOI: | 10.3390/nu17071187 |
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