The high-grade serous ovarian cancer metastasis and chemoresistance in 3D models

Tadić, Vanja; Zhang, Wei; Brozović, Anamaria (2024) The high-grade serous ovarian cancer metastasis and chemoresistance in 3D models. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1879 (1). ISSN 0304-419X

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Abstract

High-grade serous ovarian cancer (HGSOC) is the most frequent and aggressive type of epithelial ovarian cancer, with high recurrence rate and chemoresistance being the main issues in its clinical management. HGSOC is specifically challenging due to the metastatic dissemination via spheroids in the ascitic fluid. The HGSOC spheroids represent the invasive and chemoresistant cellular fraction, which is impossible to investigate in conventional two-dimensional (2D) monolayer cell cultures lacking critical cell-to-cell and cell-extracellular matrix interactions. Three-dimensional (3D) HGSOC cultures, where cells aggregate and exhibit relevant interactions, offer a promising in vitro model of peritoneal metastasis and multicellular drug resistance. This review summarizes recent studies of HGSOC in 3D culture conditions and highlights the role of multicellular HGSOC spheroids and ascitic environment in HGSOC metastasis and chemoresistance.

Item Type:	Article
Uncontrolled Keywords:	3D models; ascites; chemoresistance; high-grade serous ovarian cancer; metastasis; organoids; spheroids
Subjects:	BIOMEDICINE AND HEALTHCARE
Divisions:	Division of Molecular Biology
Depositing User:	Virna Brumnić
Date Deposited:	28 Apr 2025 10:36
URI:	http://fulir.irb.hr/id/eprint/9761
DOI:	10.1016/j.bbcan.2023.189052

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