Synthesis of Nβ-Substituted 1,2-Diazetidin-3-ones by the Ugi Reaction Comprising Chiral α-Hydrazino Acids

Suć Sajko, Josipa; Jerić, Ivanka (2022) Synthesis of Nβ-Substituted 1,2-Diazetidin-3-ones by the Ugi Reaction Comprising Chiral α-Hydrazino Acids. Journal of Organic Chemistry, 87 (11). pp. 7076-7084. ISSN 0022-3263

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Abstract

We report the synthesis of a structurally diverse library of chiral Nβ-substituted 1,2-diazetidin-3-ones by a 4-centre 3-component Ugi reaction comprising unprotected alpha-hydrazino acids. Various isocyanides and carbonyl compounds, both aldehydes and ketones were utilized. In addition, post-condensation modifications at three different sites have been demonstrated.

Item Type:	Article
Uncontrolled Keywords:	Chemical reactions; Inorganic carbon compounds; Lipids; Organic compounds; Ugi reaction
Subjects:	NATURAL SCIENCES > Chemistry > Organic Chemistry
Divisions:	Division of Organic Chemistry and Biochemistry
Projects:	Project title Project leader Project code Project type Višekomponentne reakcije u sintezi peptidnih mimetika-MIMICRy Ivanka Jerić IP-2014-09-3102 HRZZ
Depositing User:	Ivanka Jerić
Date Deposited:	08 Jan 2026 08:29
URI:	http://fulir.irb.hr/id/eprint/10725
DOI:	10.1021/acs.joc.2c00238

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