Domoic Acid: A Review of Its Cytogenotoxicity Within the One Health Approach

Gajski, Goran; Gerić, Marko; Baričević, Ana; Smodlaka Tanković, Mirta (2024) Domoic Acid: A Review of Its Cytogenotoxicity Within the One Health Approach. Antioxidants, 13 (11). ISSN 2076-3921

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Abstract

In this review, we toxicologically assessed the naturally occurring toxin domoic acid. We used the One Health approach because the impact of domoic acid is potentiated by climate change and water pollution on one side, and reflected in animal health, food security, human diet, and human health on the other. In a changing environment, algal blooms are more frequent. For domoic acid production, the growth of Pseudo-nitzschia diatoms is of particular interest. They produce this toxin, whose capability of accumulation and biomagnification through the food web impacts other organisms in the ecosystem. Domoic acid targets nervous system receptors inducing amnestic shellfish poisoning, among other less severe health-related problems. However, the impact of domoic acid on non-target cells is rather unknown, so we reviewed the currently available literature on cytogenetic effects on human and animal cells. The results of different studies indicate that domoic acid has the potential to induce early molecular events, such as oxidative imbalance and DNA damage, thus posing an additional threat which needs to be thoroughly addressed and monitored in the future.

Item Type:	Article
Uncontrolled Keywords:	domoic acid; marine biotoxin; Pseudo-nitzschia; non-target cells; cytotoxicity; genotoxicity; oxidative stress; environmental safety; public health; One Health
Subjects:	NATURAL SCIENCES > Biology
Divisions:	Center for Marine Research
Projects:	Project title Project leader Project code Project type Istraživačko-edukacijski centar za zdravstvenu i medicinsku ekologiju i zaštitu od zračenja – Rekonstrukcija i dogradnja Instituta za medicinska istraživanja i medicinu rada u Zagrebu- Radovan Fuchs; Ana Lucić Vrdoljak KK.01.1.1.02.0007 EK Procjena učinkovitosti i toksičnosti biološki aktivnih tvari Nikolina Maček Hrvat UNSPECIFIED EK Toksičnost domoične kiseline na ne-ciljne ljudske stanice Goran Gajski UNSPECIFIED HAZU
Depositing User:	Ivana Vuglec
Date Deposited:	13 Oct 2025 08:23
URI:	http://fulir.irb.hr/id/eprint/9981
DOI:	10.3390/antiox13111366

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