A hybrid multi-particle approach to range assessment-based treatment verification in particle therapy

(NOVO) Meric, Ilker; Alagoz, Enver; Hysing, Liv B.; Kögler, Toni; Lathouwers, Danny; Lionheart, William R. B.; Mattingly, John; Obhođaš, Jasmina; Pausch, Guntram; Pettersen, Helge E. S.; Ratliff, Hunter N.; Rovituso, Marta; Schellhammer, Sonja M.; Setterdahl, Lena M.; Skjerdal, Kyrre; Sterpin, Edmond; Sudac, Davorin; Turko, Joseph A.; Ytre-Hauge, Kristian S. (2023) A hybrid multi-particle approach to range assessment-based treatment verification in particle therapy. Scientific Reports, 13 (1). ISSN 2045-2322

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Abstract

Particle therapy (PT) used for cancer treatment can spare healthy tissue and reduce treatment toxicity. However, full exploitation of the dosimetric advantages of PT is not yet possible due to range uncertainties, warranting development of range-monitoring techniques. This study proposes a novel range-monitoring technique introducing the yet unexplored concept of simultaneous detection and imaging of fast neutrons and prompt-gamma rays produced in beam- tissue interactions. A quasimonolithic organic detector array is proposed, and its feasibility for detecting range shifts in the context of proton therapy is explored through Monte Carlo simulations of realistic patient models and detector resolution effects. The results indicate that range shifts of 1mm can be detected at relatively low proton intensities ( 22.30(13) x 10(7) protons/spot) when spatial information obtained through imaging of both particle species are used simultaneously. This study lays the foundation for multiparticle detection and imaging systems in the context of range verification in PT.

Item Type:	Article
Uncontrolled Keywords:	biomedical engineering; imaging techniques; three-dimensional imaging; whole body imaging
Subjects:	NATURAL SCIENCES NATURAL SCIENCES > Physics
Divisions:	Division of Experimental Physics
Depositing User:	Virna Brumnić
Date Deposited:	28 Apr 2025 12:13
URI:	http://fulir.irb.hr/id/eprint/9764
DOI:	10.1038/s41598-023-33777-w

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