Overview of metabolomic aspects in postpartum depression

Konjevod, Marcela; Gredičak, Martin; Vuić, Barbara; Tudor, Lucija; Nikolac Perković, Matea; Miloš, Tina; Švob Štrac, Dubravka; Pivac, Nela; Nedić Erjavec, Gordana (2023) Overview of metabolomic aspects in postpartum depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 127 . ISSN 0278-5846

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Abstract

Along with the typical biochemical alterations that occur during pregnancy, certain metabolic changes might be associated with the development of several psychiatric disorders, including postpartum depression (PPD), which is the most common type of psychiatric disorder during pregnancy or first postpartum year, and it develops in about 15% of women. Metabolomics is a rapidly developing discipline that deals with the metabolites as the final products of all genetically controlled biochemical pathways, highly influenced by external and internal changes. The aim of this paper was to review the published studies whose results suggest or deny a possible association between the fine regulation of the metabolome and PPD, enabling conclusions about whether metabolomics could be a useful tool in defining the biochemical pathways directly involved in the etiology, diagnosis and course of PPD. Beside numerous hormonal changes, a lot of different metabolic pathways have been discovered to be affected in women with PPD or associated with its development, including alterations in the energy metabolism, tryptophan and amino acid metabolism, steroid metabolism, purine cycle, as well as neurotransmitter metabolism. Additionally, metabolomics helped in defining the association between PPD and the exposure to various endocrine disrupting metabolites during pregnancy. Finally, metabolome reflects different PPD therapies and exposure of fetus or breastfed infants to pharmacotherapy prescribed to a mother suffering from PPD. This review can help in creating the picture about metabolomics' broad application in PPD studies, but it also implies that its potential is still not completely used.

Item Type:	Article
Uncontrolled Keywords:	Biomarkers; Hormones; Metabolites; Therapy; Xenobiotic
Subjects:	BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences > Neuroscience
Divisions:	Division of Molecular Medicine
Depositing User:	Gordana Nedić Erjavec
Date Deposited:	08 Jan 2025 08:47
URI:	http://fulir.irb.hr/id/eprint/9387
DOI:	10.1016/j.pnpbp.2023.110836

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