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Towards Platinum(II) Complexes forin celluloApplications: Synthesis, Characterization, Biological and Catalytic Evaluation

Gourdon‐Grünewaldt, Lisa; Bakija, Marija; Wild, Lara; Perić, Berislav; Gasser, Gilles; Kirin, Srećko; Cariou, Kevin (2023) Towards Platinum(II) Complexes forin celluloApplications: Synthesis, Characterization, Biological and Catalytic Evaluation. Helvetica Chimica Acta, 106 (8). ISSN 0018-019X

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Abstract

With the aim of achieving bioorthogonal intracellular catalysis, a library of platinum(II) complexes was synthesized. Their non-toxicity to living cells was demonstrated and their catalytic activity was evaluated on a cyclization reaction leading to a highly fluorescent coumarin. None of the platinum complexes showed any catalytic activity for coumarin synthesis. Still, we demonstrated that the silver salt AgSbF6 commonly used to ‘activate’ metal catalysts by removing a chloride is a very efficient catalyst for the studied intramolecular cyclization reaction.

Item Type: Article
Uncontrolled Keywords: chemical biology; catalysis; cyclization; platinum; silver
Subjects: NATURAL SCIENCES > Chemistry
Divisions: Division of Materials Chemistry
Projects:
Project titleProject leaderProject codeProject type
Inovativna rješenja u katalitičkim proizvodnim procesima za potrebe farmaceutske industrije-CAT PHARMASrećko KirinKK.01.1.1.04.0013EK
Depositing User: Marija Bakija
Date Deposited: 05 Dec 2024 15:02
URI: http://fulir.irb.hr/id/eprint/9338
DOI: 10.1002/hlca.202300078

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