The atypical CDK activator RingoA/Spy1 regulates exit from quiescence in neural stem cells

Gonzalez, Laura; Domingo-Muelas, Ana; Duart-Abadia, Pere; Nunez, Marc; Mikolčević, Petra; Llonch, Elisabet; Cubillos-Rojas, Monica; Canovas, Begona; Forrow, Stephen M.A.; Morante-Redolat, Jose Manuel; Farinas, Isabel; Angel R., Nebreda (2023) The atypical CDK activator RingoA/Spy1 regulates exit from quiescence in neural stem cells. iScience, 26 (3). ISSN 2589-0042

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Abstract

In the adult mammalian brain, most neural stem cells (NSCs) are held in a revers-ible state of quiescence, which is essential to avoid NSC exhaustion and deter-mine the appropriate neurogenesis rate. NSCs of the mouse adult subependymal niche provide neurons for olfactory circuits and can be found at different depths of quiescence, but very little is known on how their quiescence-to-activation tran-sition is controlled. Here, we identify the atypical cyclin-dependent kinase (CDK) activator RingoA as a regulator of this process. We show that the expression of RingoA increases the levels of CDK activity and facilitates cell cycle entry of a sub-set of NSCs that divide slowly. Accordingly, RingoA-deficient mice exhibit reduced olfactory neurogenesis with an accumulation of quiescent NSCs. Our re-sults indicate that RingoA plays an important role in setting the threshold of CDK activity required for adult NSCs to exit quiescence and may represent a dormancy regulator in adult mammalian tissues.

Item Type:	Article
Uncontrolled Keywords:	RingoA; CDK; NSC; quiescence
Subjects:	NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences > Neuroscience
Divisions:	Division of Molecular Biology
Depositing User:	Diana Mikoč Radešić
Date Deposited:	26 Jul 2024 11:33
URI:	http://fulir.irb.hr/id/eprint/8971
DOI:	10.1016/j.isci.2023.106202

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