One Incremental Stride for Doxycycline, One Substantial Advancement for Thyroid Eye Disease

Matoc, Ines; Kasa, Kim; Kasumović, Armin; Prpic, Ante; Vukojević, Ante; Zrinscak, Ognjen; Škunca Herman, Jelena; Doko Mandić, Blanka; Sabol, Ivan; Iveković, Renata; Vatavuk, Zoran (2024) One Incremental Stride for Doxycycline, One Substantial Advancement for Thyroid Eye Disease. Diagnostics, 14 (8). ISSN 2075-4418

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Abstract

The aim of this study is to assess the effectiveness of a 12-week doxycycline treatment for thyroid eye disease (TED), an autoimmune condition associated with thyroid dysfunction. In this randomized controlled clinical trial, 82 patients were randomly assigned at a 1:1 ratio to receive doxycycline (50 mg) or to undergo no treatment. Various metrics, including margin reflex distance (MRD1 and MRD2), eyelid aperture, levator muscle function, lagophthalmos, proptosis, ocular motility, diplopia, and Graves’ ophthalmopathy-specific quality-of-life (GO-QOL) scale scoring were assessed. Exclusion criteria were uncontrolled systemic diseases, tetracycline allergies, pregnancy, lactation, or age below 18. The mean age was 51.6 years (SD), 87.8% of participants were female, and all were Caucasians. By week 12, the doxycycline group exhibited a significant improvement rate based on MRD2 (from 4 to 15 participants with physiological findings), clinical activity score (from 7 to 35 participants with non-active disease), and GO-QOL (from 51.22% to 70.73% of participants with a good life quality). Doxycycline showcased anti-inflammatory and immunomodulatory effects in treating TED, suggesting its potential efficacy for TED and other orbit inflammatory conditions. However, these results warrant further validation through future research involving extended follow-up periods and larger cohorts.

Item Type:	Article
Uncontrolled Keywords:	doxycycline; thyroid eye disease; autoimmune thyroid dysfunction
Subjects:	BIOMEDICINE AND HEALTHCARE BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences > Ophthalmology
Divisions:	Division of Molecular Medicine
Depositing User:	Ivan Sabol
Date Deposited:	19 Jun 2024 12:38
URI:	http://fulir.irb.hr/id/eprint/8901
DOI:	10.3390/diagnostics14080791

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