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The role of mesencephalic aqueduct obstruction in hydrocephalus development: a case report

Radoš, Milan; Orešković, Darko; Klarica, Marijan (2021) The role of mesencephalic aqueduct obstruction in hydrocephalus development: a case report. Croatian Medical Journal, 62 (4). pp. 411-419. ISSN 0353-9504

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We report on three patients with mesencephalic aqueduct obstruction, which completely blocked the cerebrospinal fluid communication between the third and fourth cerebral ventricle, demonstrated by standard and high-resolution magnetic resonance sequences. Only one patient developed radiological and clinical presentation of hydrocephalus, without radiological signs of increased intraventricular pressure. The remaining two patients did not show clinical signs of hydrocephalus and had a normal radiological presentation of the ventricular system. These findings contradict the classical concept of cerebrospinal fluid physiology. This concept assumes a unidirectional circulation of cerebrospinal fluid through the mesencephalic aqueduct from the secretion site, predominantly in the choroid plexuses, to the resorption site, predominantly in the dural venous sinuses. Therefore, the obstruction of the mesencephalic aqueduct would inevitably lead to triventricular hypertensive hydrocephalus in all patients. The current observations, however, accord with the new concept of cerebrospinal fluid physiology, which postulates that cerebrospinal fluid does not circulate unidirectionally because it is both formed and resorbed along the entire capillary network within the central nervous system.

Item Type: Article
Uncontrolled Keywords: mesencephalic aqueduct obstruction; hydrocephalus
Subjects: BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences
INTERDISCIPLINARY AREAS OF KNOWLEDGE > Biotechnology in Biomedicine (natural science, biomedicine and healthcare, bioethics area
Divisions: Division of Molecular Biology
Project titleProject leaderProject codeProject type
Znanstveni centar izvrnosti - Eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi-ZCI - NEUROMiloš JudašKK.
Depositing User: Ana Zečević
Date Deposited: 27 Mar 2024 11:28
DOI: 10.3325/cmj.2021.62.411

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