Supramolecular intermediates in thermo-mechanochemical direct amidations

Stolar, Tomislav; Alić Stolar, Jasna; Talajić, Gregor; Cindro, Nikola; Rubčić, Mirta; Molčanov, Krešimir; Užarević, Krunoslav; Hernández, José G. (2023) Supramolecular intermediates in thermo-mechanochemical direct amidations. Chemical Communications, 59 (90). pp. 13490-13493. ISSN 1359-7345

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Abstract

We present a solvent-free thermo-mechanochemical approach for the direct coupling of carboxylic acids and amines, which avoids activators and additives. Detailed analysis of the reactions by ex situ and in situ monitoring methods led to the observation, isolation, and characterisation of multicomponent crystalline intermediates that precede the formation of amides. We applied our methodology for the quantitative synthesis of the active pharmaceutical ingredient moclobemide.

Item Type:	Article
Uncontrolled Keywords:	mechanochemistry; moclobemide; intermediates; pharmaceutical;
Subjects:	NATURAL SCIENCES > Chemistry > Organic Chemistry NATURAL SCIENCES > Chemistry > Applied Chemistry
Divisions:	Division of Physical Chemistry
Projects:	Project title Project leader Project code Project type Važnost mehanokemijske reaktivnosti u prebiotičkoj kemijskoj evoluciji i njezin prijenos na održivu kemijsku proizvodnju s niskim emisijama-PREBIOMECHEM Krunoslav Užarević IP-2020-02-4702 HRZZ In situ monitoring of mechanochemical cocrystal formation by synchrotron XRD Tomislav Stolar I-20220019 EC Internal DESY
Depositing User:	Krunoslav Užarević
Date Deposited:	21 Feb 2024 09:36
URI:	http://fulir.irb.hr/id/eprint/8612
DOI:	10.1039/D3CC04448C

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