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Serotonin 5-HT2A receptor polymorphisms are associated with irritability and aggression in conduct disorder

Nedić Erjavec, Gordana; Tudor, Lucija; Nikolac Perković, Matea; Podobnik, Josip; Dodig Čurković, Katarina; Čurković, Mario; Švob Štrac, Dubravka; Čusek, Melita; Bortolato, Marco; Pivac, Nela (2022) Serotonin 5-HT2A receptor polymorphisms are associated with irritability and aggression in conduct disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 117 . p. 110542. ISSN 02785846

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In childhood and adolescence, overt antisocial and aggressive manifestations are typically diagnosed as conduct disorder (CD). Given that the emerging research has pointed to the influence of 5-HT2A receptors in the ontogeny of aggression, we aimed to analyze the association of its genetic polymorphisms with CD. The study included 228 male adolescent subjects (120 with and 108 without CD). CD was diagnosed according to Structured Clinical Interview for DSM-IV criteria, while evaluations of aggressive/dissociative behaviors were performed using psychometric questionnaires including the PCL-YV, OAS-M, KADS, and CBCL. Platelet 5-HT concentration was determined by spectrophotofluorometry. Genotyping of 5-HT2A receptor polymorphisms rs2070040, rs9534511, rs4142900, rs9534512 was performed using TaqMan SNP Genotyping Assays. Subjective irritability, physical aggression toward others, and antisocial behavior were strongly associated with the G allele of rs2070040 and rs4142900, and the C allele of rs9534511 and rs9534512. A significantly increased platelet 5-HT concentration in CD subjects, compared to controls, was lost after the correction according to the smoking status. Our results indicate an association of the studied HTR2A polymorphisms and their haplotypes with irritability and impulsivity traits, which may contribute to the aggressive and antisocial behavior in male adolescents with CD.

Item Type: Article
Uncontrolled Keywords: 5-HT(2A) receptor polymorphisms ; Aggression ; Conduct disorder ; Irritability ; Serotonin
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences > Neuroscience
Divisions: Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja-Nela Pivac098-0982522-2455MZOS
Depositing User: Gordana Nedić Erjavec
Date Deposited: 08 Feb 2024 13:24
DOI: 10.1016/j.pnpbp.2022.110542

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