Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria

Ćesić, Diana; Lugović Mihić, Liborija; Ozretić, Petar; Lojkić, Ivana; Buljan, Marija; Šitum, Mirna; Zovak, Mario; Vidović, Dinko; Mijić, August; Galić, Nada; Tambić Andrašević, Arjana (2023) Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria. Life, 13 (6). ISSN 2075-1729

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Abstract

(1) Background: Chronic spontaneous urticaria (CSU) has been linked to the dysbiosis of the gut microbiota. Furthermore, various studies have highlighted the anti-inflammatory properties of short-chain fatty acids (SCFAs), whose production is primarily regulated by the gut microbiota. However, only a few studies have investigated the role of major SCFA producers, such as Lachnospiraceae, in skin inflammatory diseases. (2) Goal: This study aimed to compare the abundance of Lachnospiraceae between CSU patients and healthy controls (HCs). (3) Material and methods: In this case–control study, 16S rRNA sequencing was performed to compare the composition of the gut microbiome between 22 CSU patients and 23 HCs. (4) Results: Beta-diversity revealed significant clustering (p < 0.05) between the CSU patients and HCs. Alpha diversity in the CSU group was significantly decreased according to the Evenness index (p < 0.05). The linear discriminant analysis effect size (LEfSe) identified the significant depletion of the Lachnospiraceae family in CSU patients. (5) Conclusion: Our study revealed the dysbiosis of the gut microbiota in CSU patients, including decreased levels of Lachnospiraceae members, responsible for SCFA production, suggesting that SCFAs may contribute to immune dysfunction in the pathogenesis of CSU. We speculate that the modulation of SCFAs could serve as a prospective additional option in CSU treatment.

Item Type:	Article
Uncontrolled Keywords:	chronic spontaneous urticaria; gut microbiota; Lachnospiraceae; short-chain fatty acids
Subjects:	BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences > Human Genetics, Genomics and Proteomics BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences > Dermatovenerology BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences > Medical Microbiology
Divisions:	Division of Molecular Medicine
Projects:	Project title Project leader Project code Project type Obilježja mikrobioma i kvalitete života bolesnika s kroničnom urtikarijom- Liborija Lugović Mihić Lugović-2019 NadSve Obilježja mikrobioma i kvalitete života bolesnika s kroničnom urtikarijom- Liborija Lugović Mihić Lugović-2020 NadSve Ispitivanje mikrobioma kože kod bolesnika s periorificijalnim dermatitisom- Arjana Tambić Andrašević Tambić-2019 NadSve Ispitivanje mikrobioma kože kod bolesnika s periorofacijalnim dermatitisom- Arjana Tambić Andrašević Tambić-2020 NadSve Ispitivanje mikrobioma kože i povezanost s alergijama u bolesnika s periorificijalnim dermatitisom- Arjana Tambić Andrašević Tambić-2021 NadSve Povezanost obilježja mikrobioma, psihičkog stresa i upale kože- Liborija Lugović Mihić Lugović-2021 NadSve
Depositing User:	Dr.sc. Petar Ozretić
Date Deposited:	08 Feb 2024 09:56
URI:	http://fulir.irb.hr/id/eprint/8547
DOI:	10.3390/life13061280

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