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The Impact of Severe COVID-19 on Plasma Antioxidants

Žarković, Neven; Jastrząb, Anna; Jarocka-Karpowicz, Iwona; Orehovec, Biserka; Baršić, Bruno; Tarle, Marko; Kmet, Marta; Lukšić, Ivica; Łuczaj, Wojciech; Skrzydlewska, Elżbieta (2022) The Impact of Severe COVID-19 on Plasma Antioxidants. Molecules, 27 (16). ISSN 1420-3049

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Several studies suggested the association of COVID-19 with systemic oxidative stress, in particular with lipid peroxidation and vascular stress. Therefore, this study aimed to evaluate the antioxidant signaling in the plasma of eighty-eight patients upon admission to the Clinical Hospital Dubrava in Zagreb, of which twenty-two died within a week, while the other recovered. The differences between the deceased and the survivors were found, especially in the reduction of superoxide dismutases (SOD-1 and SOD-2) activity, which was accompanied by the alteration in glutathione-dependent system and the intensification of the thioredoxin-dependent system. Reduced levels of non-enzymatic antioxidants, especially tocopherol, were also observed, which correlated with enhanced lipid peroxidation (determined by 4-hydroxynonenal (4-HNE) and neuroprostane levels) and oxidative modifications of proteins assessed as 4-HNE-protein adducts and carbonyl groups. These findings confirm the onset of systemic oxidative stress in patients with severe SARS-CoV-2, especially those who died from COVID-19, as manifested by strongly reduced tocopherol level and SOD activity associated with lipid peroxidation. Therefore, we propose that preventive and/or supplementary use of antioxidants, especially of lipophilic nature, could be beneficial for the treatment of COVID-19 patients.

Item Type: Article
Uncontrolled Keywords: COVID-19; SARS-CoV-2; biomarkers; plasma; antioxidants; GSH system; Trx system; lipid peroxidation; 4-HNE-protein adducts
Subjects: BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences
Divisions: Division of Molecular Medicine
Depositing User: Diana Mikoč Radešić
Date Deposited: 02 Feb 2024 09:14
DOI: 10.3390/molecules27165323

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