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Drug delivery by TAT-technology

Grdiša, Mirica; Mikecin, Ana-Matea (2008) Drug delivery by TAT-technology. Croatica Chemica Acta, 81 (2). pp. 223-226. ISSN 0011-1643

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TAT technology is a biochemical technique for introduction of full-length peptides or proteins into cells. This process occurs in a rapid, concentration-dependent fashion that appears to be independent of receptors and transporters. It has broad implications in experimental systems for regulating intracellular processes and has the potential to be used in the development of new therapeutic strategies for cancer, infectious diseases, and development of vaccines. It has been shown that different forms of TAT-p27 protein can modulate the cell cycle of cultured cell lines, depending on the concentration and type of cells. Transfer of TAT-proteins/peptides use from cell culture systems to animal disease models has been slow, but the ability of TAT conjugates to protect mice against ischemia, inhibit tumor growth, and enhance gene delivery suggests that they offer wide ranging pharmaceutical applications for treating a whole range of diseases.

Item Type: Article
Uncontrolled Keywords: TAT-vector; protein transduction; drug delivery; cell-penetrating peptides; vivo protein transduction; ischemic brain injury; hiv-1 tat; intracellular delivery; neuronal apoptosis; fusion protein; bcl-xl; macropinocytosis; internalization
Subjects: NATURAL SCIENCES > Chemistry
Divisions: Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Molekularna obilježja miofibroblasta Dupuytrenove bolesti[35262] Krešimir Pavelić098-0982464-2393MZOS
Depositing User: Mirica Grdiša
Date Deposited: 23 Oct 2013 11:14

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