Ochratoxin A potentiates citrinin accumulation in kidney and liver of rats

Rašić, Dubravka; Stefanović, Srđan; Milićević, Dragan; Mladinić, Marin; Želježić, Davor; Pizent, Alica; Konjevoda, Paško; Peraica, Maja (2022) Ochratoxin A potentiates citrinin accumulation in kidney and liver of rats. Arhiv za higijenu rada i toksikologiju, 73 (1). pp. 43-47. ISSN 1848-6312

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Abstract

Ochratoxin A (OTA) and citrinin (CTN) are nephrotoxic mycotoxins often found together in grain. The aim of this study was to measure their accumulation in the kidney and liver of adult male Wistar rats, see how it would be affected by combined treatment, and to determine if resveratrol (RSV) would decrease their levels in these organs. The rats received 125 or 250 mg/kg bw of OTA by gavage every day for 21 days and/or 20 mg/kg bw of CTN a day for two days. Two groups of rats treated with OTA+CTN were also receiving 20 mg/kg bw of RSV a day for 21 days. In animals receiving OTA alone, its accumulation in both organs was dose-dependent. OTA+CTN treatment resulted in lower OTA but higher CTN accumulation in both organs at both OTA doses. RSV treatment increased OTA levels in the kidney and liver and decreased CTN levels in the kidney. Our findings point to the competition between CTN and OTA for organic anion transporters 1 and 3.

Item Type:	Article
Uncontrolled Keywords:	experimental rats; mycotoxins; organic anion transporters; resveratrol; toxicity
Subjects:	BIOMEDICINE AND HEALTHCARE
Divisions:	Division of Molecular Medicine
Depositing User:	Lorena Palameta
Date Deposited:	13 Dec 2023 13:37
URI:	http://fulir.irb.hr/id/eprint/8307
DOI:	10.2478/aiht-2022-73-3605

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