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Rapid Voltammetric Identification and Determination of Simvastatin at Trace Levels in Pharmaceuticals and Biological Fluid

Nigović, Biljana; Komorsky-Lovrić, Šebojka; Devčić, Dubravka (2008) Rapid Voltammetric Identification and Determination of Simvastatin at Trace Levels in Pharmaceuticals and Biological Fluid. Croatica Chemica Acta, 81 (3). pp. 453-459. ISSN 0011-1643

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Abstract

Simvastatin is used as all antilipemic agent through inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. The reduction behavior of drug has been studied in different supporting electrolytes within the pH range 3-9. Based oil the adsorptive character of simvastatin onto the mercury electrode surface, a new cathodic square-wave stripping voltammetry method for its direct determination at trace levels has been proposed. The voltammetric response could be used to determine drug concentration in the range 1.0 x 10(-8) to 7.5 x 10(-7) mol L(-1), with detection limit of 4.5 x 10(-9) mol L(-1). Applicability to biological fluid analysis was illustrated. The method was successfully employed, without sample pretreatment, for quantitation of the active ingredient simvastatin in pharmaceuticals. The use of abrasive stripping voltammetry for rapid identification of this drug in pharmaceutical dosage forms using a paraffin-impregnated graphite electrode has been examined.

Item Type: Article
Uncontrolled Keywords: simvastatin; square-wave voltammetry; abrasive stripping voltammetry; pharmaceuticals; biological fluid; performance liquid-chromatography; human plasma; reductase inhibitors; mass-spectrometry; acid form; samples; pravastatin; lovastatin; oxidation
Subjects: NATURAL SCIENCES > Chemistry
Divisions: Division for Marine and Enviromental Research
Projects:
Project titleProject leaderProject codeProject type
Elektroanalitička istraživanja mikrokristala i tragova otopljenih supstanci[26554] Milivoj Lovrić098-0982904-2907MZOS
Istraživanje novih metoda u analitici ljekovitih i bioaktivnih tvari[149044] Biljana Nigović006-0061117-1240MZOS
Depositing User: Šebojka Komorsky-Lovrić
Date Deposited: 23 Oct 2013 08:49
Last Modified: 14 Feb 2014 14:37
URI: http://fulir.irb.hr/id/eprint/829

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