Nigović, Biljana; Komorsky-Lovrić, Šebojka; Devčić, Dubravka
Rapid Voltammetric Identification and Determination of Simvastatin at Trace Levels in Pharmaceuticals and Biological Fluid.
Croatica Chemica Acta, 81
Simvastatin is used as all antilipemic agent through inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. The reduction behavior of drug has been studied in different supporting electrolytes within the pH range 3-9. Based oil the adsorptive character of simvastatin onto the mercury electrode surface, a new cathodic square-wave stripping voltammetry method for its direct determination at trace levels has been proposed. The voltammetric response could be used to determine drug concentration in the range 1.0 x 10(-8) to 7.5 x 10(-7) mol L(-1), with detection limit of 4.5 x 10(-9) mol L(-1). Applicability to biological fluid analysis was illustrated. The method was successfully employed, without sample pretreatment, for quantitation of the active ingredient simvastatin in pharmaceuticals. The use of abrasive stripping voltammetry for rapid identification of this drug in pharmaceutical dosage forms using a paraffin-impregnated graphite electrode has been examined.
||simvastatin; square-wave voltammetry; abrasive stripping voltammetry; pharmaceuticals; biological fluid; performance liquid-chromatography; human plasma; reductase inhibitors; mass-spectrometry; acid form; samples; pravastatin; lovastatin; oxidation
||NATURAL SCIENCES > Chemistry
||Division for Marine and Enviromental Research
|Project title||Project leader||Project code||Project type|
|Elektroanalitička istraživanja mikrokristala i tragova otopljenih supstanci|| Milivoj Lovrić||098-0982904-2907||MZOS|
|Istraživanje novih metoda u analitici ljekovitih i bioaktivnih tvari|| Biljana Nigović||006-0061117-1240||MZOS|
||23 Oct 2013 08:49
||14 Feb 2014 14:37
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