hrvatski jezikClear Cookie - decide language by browser settings

Association of Oxidative-Stress-Related Gene Polymorphisms with Pain-Related Temporomandibular Disorders and Oral Behavioural Habits

Vrbanović, Ema; Zlendić, Marko; Gall Trošelj, Koraljka; Tomljanović, Marko; Vuković Đerfi, Kristina; Alajbeg, Iva (2023) Association of Oxidative-Stress-Related Gene Polymorphisms with Pain-Related Temporomandibular Disorders and Oral Behavioural Habits. Antioxidants, 12 (6). ISSN 2076-3921

PDF - Published Version - article
Available under License Creative Commons Attribution.

Download (1MB) | Preview


The frequency of selected polymorphisms, one in each gene coding for proteins with antioxidative properties (CAT(rs1001179), SOD2(rs4880), GPX1(rs1050450), and NQO1(rs689452)), was compared between patients suffering from pain-related temporomandibular disorders (TMDp ; n = 85) and control subjects (CTR ; n = 85). The same was evaluated when participants were divided with respect to oral behavioural habits frequency into high-frequency parafunction (HFP ; n = 98) and low- frequency parafunction (LFP ; n = 72) groups. Another aim was to investigate whether polymorphisms in these genes can be associated with participants’ psychological and psychosomatic characteristics. Polymorphisms were genotyped using the genomic DNA extracted from buccal mucosa swabs and real-time TaqMan genotyping assays. No differences in genotype distribution between TMDp patients and control subjects were found. Still, TMDp patients who were homozygous for minor allele A, related to the GPX1 polymorphism rs1050450, reported significantly more waking-state oral behaviours than GA + GG genotype carriers (score: 30 vs. 23, p = 0.019). The frequency of genotype AA for rs1050450 polymorphism was higher in HFP than in LFP participants (14.3% vs. 4.2%, p = 0.030). The most important predictors of waking- state oral behaviours were depression, anxiety, AA genotype (rs1050450), and female sex. The explored gene polymorphisms were not found to be significant risk factors for either TMDp or sleep- related oral behaviours. The association of waking-state oral behaviours with selected gene polymorphisms additionally supports previous assumptions that daytime bruxism is more closely linked to various stress manifestations, which might also be reflected through the variability related to the cellular antioxidative activity.

Item Type: Article
Uncontrolled Keywords: chronic orofacial pain ; oxidative-stress-related genes ; temporomandibular disorders ; oral behavioural habits ; single-nucleotide polymorphism
Subjects: BIOMEDICINE AND HEALTHCARE > Dental Medicine
Divisions: Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Povezanost genskih polimorfizama s temporomandibularnim poremećajimaAlajbeg, IvaIP-2019-04-6211HRZZ
Depositing User: Koraljka Gall Trošelj
Date Deposited: 06 Jul 2023 12:21
DOI: 10.3390/antiox12061195

Actions (login required)

View Item View Item


Downloads per month over past year

Increase Font
Decrease Font
Dyslexic Font