hrvatski jezikClear Cookie - decide language by browser settings

The role of solid-state reactivity in the prebiotic selection of nucleobases and the formation of peptides

Stolar, Tomislav (2022) The role of solid-state reactivity in the prebiotic selection of nucleobases and the formation of peptides. Doctoral thesis, University of Zagreb, Faculty of Science.

| Request a personal copy from author


Within this thesis, solid-state reaction medium and mechanochemical methodologies were explored to unveil weather nucleobases can self-assemble and amino acids can oligomerize under these conditions. X-ray diffraction and differential scanning calorimetry analysis showed that 2,6-diaminopurine (D) selectively self-assembles with uracil (U) and thymine (T), while adenine (A) self-assembles with hypoxanthine (H). Crystal structures of D-U cocrystal hydrate, D-T cocrystal hydrate, D-T cocrystal anhydrate, A-H cocrystal hydrate, and A-H cocrystal anhydrate were determined from powder X-ray diffraction and single-crystal X-ray diffraction data. Ion-pairing high performance liquid chromatography and mass spectrometry analysis showed that glycine and alanine undergo oligomerization by mechanical activation. Based on the results, it can be concluded that minerals as additives, time, mechanical loading, and temperature are all important parameters for the mechanochemical prebiotic peptide synthesis. In summary, solid-state reactivity of nucleobases and amino acids might have been an important factor in their prebiotic chemical evolution.

Item Type: Thesis (Doctoral thesis)
Uncontrolled Keywords: amino acids; mechanochemistry; molecular recognition; nucleobases; peptides; prebiotic chemistry; solid-state reactivity
Subjects: NATURAL SCIENCES > Chemistry
Divisions: Division of Physical Chemistry
Project titleProject leaderProject codeProject type
Važnost mehanokemijske reaktivnosti u prebiotičkoj kemijskoj evoluciji i njezin prijenos na održivu kemijsku proizvodnju s niskim emisijama-PREBIOMECHEMKrunoslav UžarevićIP-2020-02-4702HRZZ
Depositing User: Tomislav Stolar
Date Deposited: 28 Jun 2023 12:57

Actions (login required)

View Item View Item


Downloads per month over past year

Increase Font
Decrease Font
Dyslexic Font