EZH2 Inhibition and Cisplatin as a Combination Anticancer Therapy: An Overview of Preclinical Studies

Samaržija, Ivana; Tomljanović, Marko; Novak Kujundžić, Renata; Gall Trošelj, Koraljka (2022) EZH2 Inhibition and Cisplatin as a Combination Anticancer Therapy: An Overview of Preclinical Studies. Cancers, 14 (19). ISSN 2072-6694

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Abstract

Anticancer monotherapies are often insufficient in eradicating cancer cells because cancers are driven by changes in numerous genes and pathways. Combination anticancer therapies which aim to target several cancer traits at once represent a substantial improvement in anticancer treatment. Cisplatin is a conventional chemotherapy agent widely used in the treatment of different cancer types. However, the shortcomings of cisplatin use include its toxicity and development of resistance. Therefore, from early on, combination therapies that include cisplatin were considered and used in a variety of cancers. EZH2, an epigenetic regulator, is frequently upregulated in cancers which, in general, potentiates cancer cell malignant behavior. In the past decade, numerous EZH2 inhibitors have been explored for their anticancer properties. In this overview, we present the studies that discuss the joint action of cisplatin and EZH2 inhibitors. According to the data presented, the use of cisplatin and EZH2 inhibitors may be beneficial in the treatment of lung, ovarian, and breast cancers, since there is a substantial amount of published evidence that suggests their concerted action. However, in testicular germ cell tumors, such a combination would not be recommended because cisplatin resistance seems to be associated with decreased expression of EZH2 in this tumor type.

Item Type:	Article
Uncontrolled Keywords:	: cisplatin ; EZH2 ; EZH2 inhibitors ; drug resistance ; combination therapy ; targeted anticancer therapy ; lung cancer ; ovarian cancer ; breast cancer ; testicular germ cell tumors
Subjects:	NATURAL SCIENCES > Biology
Divisions:	Division of Molecular Medicine
Depositing User:	Ivana Samaržija
Date Deposited:	06 Apr 2023 10:52
URI:	http://fulir.irb.hr/id/eprint/7890
DOI:	10.3390/cancers14194761

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