hrvatski jezikClear Cookie - decide language by browser settings

Influence of Biomacromolecules on Calcium Phosphate Formation on TiO2 Nanomaterials

Erceg, Ina; Dutour Sikirić, Maja (2022) Influence of Biomacromolecules on Calcium Phosphate Formation on TiO2 Nanomaterials. Minerals, 12 (12). ISSN 2075-163X

PDF - Published Version - article
Available under License Creative Commons Attribution.

Download (2MB) | Preview


Calcium phosphates (CaP) composites with biomacromolecules and/or nanomaterials have recently emerged as a potential solution to improve the poor mechanical properties and biological response of CaP. Among the methods available for preparation of such composites, precipitation at low temperatures attracts special interest as it allows preservation of the activity of biomacromolecules. However, precipitation of CaP in the presence of two additives is a complex process that needs to be studied in detail to rationalize composite preparation. This study aimed to investigate co- precipitation of CaP on different TiO2 nanomaterials (TiNMs), including nanoparticles (TiNPs), nanoplates (TiNPls), nanotubes (TiNTs), and nanowires (TiNWs), in the presence of bovine serum albumin (BSA) and chitosan (Chi). The obtained results have shown that both BSA and Chi inhibited transformation of amorphous to crystalline CaP, even in the presence of TiNMs at concentrations that promoted transformation. Chi proved to be a stronger inhibitor due to its more flexible structure. The presence of BSA and Chi did not influence the composition of the CaP formed as calcium-deficient hydroxyapatite (CaDHA) was formed in all the systems. However, both macromolecules influenced the morphology of the formed CaDHA in different ways depending on the type of TiNM used. BSA and Chi adsorbed on all the TiNMs, as confirmed by zeta potential measurements, but this adsorption reduced the amount of CaP formed on TiNMs only in the case of TiNWs. The obtained results contribute to the understanding of the influence of BSA and Chi on CaP precipitation in the presence of nanomaterials and thus to the rational design of CaP-based multi-composite materials.

Item Type: Article
Uncontrolled Keywords: calcium-deficient hydroxyapatite ; bovine serum albumin ; chitosan ; precipitation
Subjects: NATURAL SCIENCES > Chemistry
NATURAL SCIENCES > Interdisciplinary Natural Sciences
TECHNICAL SCIENCES > Chemical Engineering
Divisions: Division of Physical Chemistry
Project titleProject leaderProject codeProject type
Mehanizmi nastajanja kalcijevih fosfata na anorganskim nanomaterijalima. Biomimetski put priprave multifunkcionalnih kompozita za regeneraciju čvrstih tkivaDutour Sikirić, MajaIP-2018-01-1493HRZZ
Depositing User: Maja Dutour Sikirić
Date Deposited: 04 Apr 2023 13:16
DOI: 10.3390/min12121557

Actions (login required)

View Item View Item


Downloads per month over past year

Increase Font
Decrease Font
Dyslexic Font