The Fine-Tuned Release of Antioxidant from Superparamagnetic Nanocarriers under the Combination of Stationary and Alternating Magnetic Fields

Mandić, Lucija; Sadžak, Anja; Erceg, Ina; Baranović, Goran; Šegota, Suzana (2021) The Fine-Tuned Release of Antioxidant from Superparamagnetic Nanocarriers under the Combination of Stationary and Alternating Magnetic Fields. Antioxidants, 10 (8). pp. 1212-1231. ISSN 2076-3921

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Official URL: https://www.mdpi.com/2076-3921/10/8/1212

Abstract

Superparamagnetic magnetite nanoparticles (MNPs) with excellent biocompatibility and negligible toxicity were prepared by solvothermal method and stabilized by widely used and biocompatible polymer poly(ethylene glycol) PEG-4000 Da. The unique properties of the synthesized MNPs enable them to host the unstable and water-insoluble quercetin as well as deliver and localize quercetin directly to the desired site. The chemical and physical properties were validated by X-ray powder diffraction (XRPD), field emission scanning electron microscopy (FE–SEM), atomic force microscopy (AFM), superconducting quantum interference device (SQUID) magnetometer, FTIR spectroscopy and dynamic light scattering (DLS). The kinetics of in vitro quercetin release from MNPs followed by UV/VIS spectroscopy was controlled by employing combined stationary and alternating magnetic fields. The obtained results have shown an increased response of quercetin from superparamagnetic MNPs under a lower stationary magnetic field and s higher frequency of alternating magnetic field. The achieved findings suggested that we designed promising targeted quercetin delivery with fine-tuning drug release from magnetic MNPs.

Item Type:

Article

Uncontrolled Keywords:

release kinetics ; superparamagnetism ; stationary magnetic field ; alternating magnetic fields ; magnetic nanoparticles ; quercetin

Subjects:

NATURAL SCIENCES > Chemistry

Divisions:

Division of Physical Chemistry

Projects:

Project title	Project leader	Project code	Project type
Zaštitni mehanizmi i učinci flavonoida ugrađenih u nanonosače u modelnim membranama i neuronima-NanoFlavNeuroProtect	Suzana Šegota	IP-2016-06-8415	HRZZ

Depositing User:

Kristina Ciglar

Date Deposited:

05 Dec 2022 14:55

URI:

http://fulir.irb.hr/id/eprint/7696

DOI:

10.3390/antiox10081212