Lipid peroxidation in brain tumors

Jaganjac, Morana; Cindrić, Marina; Jakovčević, Antonia; Žarković, Kamelija; Žarković, Neven (2021) Lipid peroxidation in brain tumors. Neurochemistry international, 149 . ISSN 0197-0186

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Abstract

Lipid peroxidation is achieved by two main pathways, enzymatic and non-enzymatic oxidation. In this paper, we focus on non- enzymatic, self-catalyzed chain reaction of poly-unsaturated fatty acid (PUFA) peroxidation generating reactive aldehydes, notably 4- hydroxynonenal (4-HNE), which acts as a second messenger of free radicals and a growth regulating factor. There is enough evidence showing that lipid peroxidation plays very important role in development of various diseases, including neurodegenerative diseases and brain tumors. Its origin might be from astrocytes as well as from blood vessels, also within the blood-brain barrier (BBB), which is in case of brain tumors transformed into the blood-brain-tumor barrier (BBTB). The functionality of the BBB is strongly affected by 4-HNE, which forms relatively stable protein adducts thus allowing the persistence and spread of lipid peroxidation, as revealed by immunohistochemical findings. Because 4-HNE can act as a regulator of vital functions of normal and of malignant cells acting in the cell-type and concentration-dependent manners, the bioactivities of this reactive aldehyde should further be studied to reveal if it acts as a co-factor of carcinogenesis or/and as a factor of defense against primary brain tumors and metastatic cancer.

Item Type:	Article
Uncontrolled Keywords:	central nervous system ; brain ; oxidative stress ; lipid peroxidation ; 4-hydrodxynonenal ; cancer ; metastases ; blood-brain barrier ; astrocytes ; glioblastoma ; blood vessels
Subjects:	NATURAL SCIENCES NATURAL SCIENCES > Biology BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences > Cytology, Histology and Embryology BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences > Neuroscience BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences > Oncology BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences > Pathology
Divisions:	Division of Molecular Medicine
Depositing User:	Neven Žarković
Date Deposited:	06 Dec 2022 14:12
URI:	http://fulir.irb.hr/id/eprint/7687
DOI:	10.1016/j.neuint.2021.105118

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