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Conjugates of Classical DNA/RNA Binder with Nucleobase: Chemical, Biochemical and Biomedical Applications

Saftić, Dijana; Ban, Željka; Matić, Josipa; Tumir, Lidija-Marija; Piantanida, Ivo (2019) Conjugates of Classical DNA/RNA Binder with Nucleobase: Chemical, Biochemical and Biomedical Applications. Current Medicinal Chemistry, 26 (30). pp. 5609-5624. ISSN 0929-8673

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Among the most intensively studied classes of small molecules (molecular weight < 650) in biomedical research are small molecules that non-covalently bind to DNA/RNA, and another intensively studied class is nucleobase derivatives. Both classes have been intensively elaborated in many books and reviews. However, conjugates consisting of DNA/RNA binder covalently linked to nucleobase are much less studied and have not been reviewed in the last two decades. Therefore, this review summarized reports on the design of classical DNA/RNA binder – nucleobase conjugates, as well as data about their interactions with various DNA or RNA targets, and even in some cases protein targets are involved. According to these data, the most important structural aspects of selective or even specific recognition between small molecule and target are proposed, and where possible related biochemical and biomedical aspects were discussed. The general conclusion is that this, rather new class of molecules showed an amazing set of recognition tools for numerous DNA or RNA targets in the last two decades, as well as few intriguing in vitro and in vivo selectivities. Several lead research lines show promising advancements toward either novel, highly selective markers or bioactive, potentially druggable molecules.

Item Type: Article
Uncontrolled Keywords: DNA ; RNA recognition ; aryl-nucleobase conjugate ; fluorescence ; circular dichroism ; bioimaging, cytotoxicity
NATURAL SCIENCES > Chemistry > Organic Chemistry
NATURAL SCIENCES > Chemistry > Applied Chemistry
NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology
Divisions: Division of Organic Chemistry and Biochemistry
Project titleProject leaderProject codeProject type
Višenamjensko očitavanje DNA/RNA sekundarne strukture molekularnim kemijskim senzorima-DNA/RNA-MolSenseIvo Piantanida; Carsten Schmuck; Tamara ŠmidlehnerIP-2013-11-1477HRZZ
Depositing User: Dijana Pavlović Saftić
Date Deposited: 02 Sep 2022 11:54
DOI: 10.2174/0929867325666180508090640

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