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Salivary Scca1, Scca2 and Trop2 in Oral Cancer Patients-A Cross-Sectional Pilot Study

Karmelić, Ivana; Salarić, Ivan; Baždarić, Ksenija; Rožman, Marko; Zajc, Ivan; Mravak-Stipetić, Marinka; Bago, Ivona; Brajdić, Davor; Lovrić, Jasna; Macan, Darko (2022) Salivary Scca1, Scca2 and Trop2 in Oral Cancer Patients-A Cross-Sectional Pilot Study. Dentistry journal, 10 (4). ISSN 2304-6767

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Oral squamous cell carcinoma (OSCC) is frequently diagnosed in the advanced stages. The purpose of this paper is to determine the salivary values of SCCA1, SCCA2 and TROP2 in patients with T1N0M0 OSCC and to compare them with the values obtained from healthy individuals. Unstimulated (UWS) and stimulated (SWS) saliva was sampled from 29 patients with T1N0M0 OSCC and 29 sex- and age- matched healthy individuals. Statistical difference was observed in SCCA1 and SCCA2 levels both in UWS and SWS samples. TROP2 was not measurable in most of the salivary samples. Both SCCA1 and SCCA2 could represent potential biomarkers for the early-stage OSCC. Research on a larger sample and biomarker validation is needed to assess the clinical potential of SCCA1 and SCCA2 in the OSCC early diagnostics.

Item Type: Article
Uncontrolled Keywords: oral cancer ; early diagnosis ; biomarkers ; saliva
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences
Divisions: Division of Physical Chemistry
Project titleProject leaderProject codeProject type
Izolacija, kvantifikacija i kinetika salivarnih Ap4A, SCCA i TROP2 kod pacijenata s oralnim karcinomom i potencijalno malignim poremećajimaMacan, DarkoIP-2014-09-9376HRZZ
Depositing User: Marko Rožman
Date Deposited: 02 May 2022 11:58
DOI: 10.3390/dj10040070

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