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HPV-associated oncogenesis in head and neck cancer

Tomaić, Vjekoslav; Milutin Gašperov, Nina; Sabol, Ivan; Grce, Magdalena (2022) HPV-associated oncogenesis in head and neck cancer. Liječnički vjesnik, 144 (3-4). pp. 106-111. ISSN 0024-3477

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More than 200 human papillomaviruses (HPVs) infect human epithelial cells, and out of them alpha and beta types have been the most extensively investigated and analysed. Alpha HPVs primarily infect mucosal epithelia and only a small proportion of them is associated with more than 600,000 cancers per year worldwide at various anatomical sites, especially anogenital and head-and-neck region. Of these the central disease is cervical cancer, which is the leading cause of cancer-related deaths in women in numerous parts of the world. HPVs encode two oncoproteins, E6 and E7, which are directly involved in the development of HPV-mediated malignancies. They do this in cooperation by targeting various cellular pathways involved in the regulation of cell cycle control, of apoptosis and of cell polarity control networks. In this review, the biological consequences of HPV manipulating of various cellular proteins at diverse anatomical sites in the development of HPV-induced carcinogenesis are depicted, with focus on head and neck cancer.

Item Type: Article
Uncontrolled Keywords: HPV ; oncogenesis ; HNSCC
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences > Oncology
Divisions: Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Rasvjetljivanje onkogenih funkcija E6/E7 HPV-a na različitim anatomskim mjestima-HPVHNCVjekoslav TomaićIP-2016-06-2246HRZZ
Epigenetičke promjene karcinoma pločastih stanica glave i vrata-EpiC-HNSCCMagdalena GrceIP-2013-11-4758HRZZ
Depositing User: Ivan Sabol
Date Deposited: 06 Apr 2022 08:25
DOI: 10.26800/lv-144-3-4-7

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