hrvatski jezikClear Cookie - decide language by browser settings

Angiotensin-converting Enzyme 2 (ACE2) as a potential diagnostic and prognostic biomarker for chronic inflammatory lung diseases

Marčetić, Dejan; Samaržija, Miroslav; Vukić Dugac, Andrea; Knežević, Jelena (2021) Angiotensin-converting Enzyme 2 (ACE2) as a potential diagnostic and prognostic biomarker for chronic inflammatory lung diseases. Genes, 12 (7). ISSN 2073-4425

PDF - Published Version - article
Available under License Creative Commons Attribution.

Download (942kB) | Preview


Chronic inflammatory lung diseases are characterized by uncontrolled immune response in the airways as their main pathophysiological manifestation. The lack of specific diagnostic and therapeutic biomarkers for many pulmonary diseases represents a major challenge for pulmonologists. The majority of the currently approved therapeutic approaches are focused on achieving disease remission, although there is no guarantee of complete recovery. It is known that angiotensin-converting enzyme 2 (ACE2), an important counter-regulatory component of the renin–angiotensin–aldosterone system (RAAS), is expressed in the airways. It has been shown that ACE2 plays a role in systemic regulation of the cardiovascular and renal systems, lungs and liver by acting on blood pressure, electrolyte balance control mechanisms and inflammation. Its protective role in the lungs has also been presented, but the exact pathophysiological mechanism of action is still elusive. The aim of this study is to review and discuss recent findings about ACE2, including its potential role in the pathophysiology of chronic inflammatory lung diseases:, i.e., chronic obstructive pulmonary disease, asthma, and pulmonary hypertension. Additionally, in the light of the coronavirus 2019 disease (COVID-19), we will discuss the role of ACE2 in the pathophysiology of this disease, mainly represented by different grades of pulmonary problems. We believe that these insights will open up new perspectives for the future use of ACE2 as a potential biomarker for early diagnosis and monitoring of chronic inflammatory lung diseases.

Item Type: Article
Uncontrolled Keywords: angiotensin-converting enzyme 2 (ACE2) ; renin-angiotensin-aldosterone system (RAAS) ; chronic inflammatory lung diseases
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences > Human Genetics, Genomics and Proteomics
Divisions: Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Genetički i epigenetički biomarkeri urođene imunosti u KOPB-u i karcinomu pluća-LungInflaCareJelena KneževićIP-2016-06-1441HRZZ
Depositing User: Jelena Knežević
Date Deposited: 04 Apr 2022 13:37
DOI: 10.3390/genes12071054

Actions (login required)

View Item View Item


Downloads per month over past year

Increase Font
Decrease Font
Dyslexic Font