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The associations between COMT and MAO-B genetic variants with negative symptoms in patients with schizophrenia

Madžarac, Zoran; Tudor, Lucija; Šagud, Marina; Nedić Erjavec, Gordana; Mihaljević Peleš, Alma; Pivac, Nela (2021) The associations between COMT and MAO-B genetic variants with negative symptoms in patients with schizophrenia. Current Issues in Molecular Biology, 43 (2). pp. 618-636. ISSN 1467-3045

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Negative symptoms of schizophrenia, including anhedonia, represent a heavy burden on patients and their relatives. These symptoms are associated with cortical hypodopamynergia and impaired striatal dopamine release in response to reward stimuli. Catechol-O-methyltransferase (COMT) and monoamine oxidase type B (MAO-B) degrade dopamine and affect its neurotransmission. The study determined the association between COMT rs4680 and rs4818, MAO-B rs1799836 and rs6651806 polymorphisms, the severity of negative symptoms, and physical and social anhedonia in schizophrenia. Sex-dependent associations were detected in a research sample of 302 patients with schizophrenia. In female patients with schizophrenia, the presence of the G allele or GG genotype of COMT rs4680 and rs4818, as well as GG haplotype rs4818-rs4680, which were all related to higher COMT activity, was associated with an increase in several dimensions of negative symptoms and anhedonia. In male patients with schizophrenia, carriers of the MAO-B rs1799836 A allele, presumably associated with higher MAO-B activity, had a higher severity of alogia, while carriers of the A allele of the MAO-B rs6651806 had a higher severity of negative symptoms. These findings suggest that higher dopamine degradation, associated with COMT and MAO-B genetic variants, is associated with a sex-specific increase in the severity of negative symptoms in schizophrenia patients.

Item Type: Article
Uncontrolled Keywords: COMT ; MAO-B ; alogia ; anhedonia ; negative symptoms ; patients ; polymorphisms ; schizophrenia ; sex-differences
Subjects: BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences
Divisions: Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećajaPivac, Nela098-0982522-2455MZOS
Depositing User: Lucija Tudor
Date Deposited: 04 Apr 2022 09:55
DOI: 10.3390/cimb43020045

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