Barešić, Luka; Margetić, Davor; Glasovac, Zoran (2021) Cycloaddition of Thiourea- and Guanidine-Substituted Furans to Dienophiles: A Comparison of the Environmentally-Friendly Methods. In: Chemistry Proceedings. .
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Abstract
The cycloaddition strategy was employed in order to obtain a 7-oxanorbornene framework substituted with a guanidine moiety or its precursor functional groups: protected amine or thiourea. In order to optimize the conditions for the cycloaddition, several environmentally-friendly methods—microwave assisted organic synthesis, high pressure synthesis, high speed vibrational milling, and ultrasound assisted synthesis—were employed. The outcomes of the cycloaddition reactions were interpreted in terms of endo/exo selectivity, the conversion of the reactants to the product, and the isolated yields. In general, our results indicated the HP and HSVM approaches as the methods of choice to give good yields and conversions.
| Item Type: | Conference or workshop item published in conference proceedings (UNSPECIFIED) |
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| Uncontrolled Keywords: | cycloaddition; guanidine; microwave assisted organic reactions; high pressure; high speed vibrational milling; ultrasound |
| Subjects: | NATURAL SCIENCES > Chemistry |
| Divisions: | Division of Organic Chemistry and Biochemistry |
| Depositing User: | Lovorka Čaja |
| Date Deposited: | 29 Mar 2022 08:30 |
| URI: | http://fulir.irb.hr/id/eprint/7122 |
| DOI: | 10.3390/ecsoc-24-08380 |
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