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NanoUPLC-QTOF-MS/MS Determination of Major Rosuvastatin Degradation Products Generated by Gamma Radiation in Aqueous Solution

Dončević, Lucija; Svetličić, Ema; Hozić, Amela; Mihaljević, Branka; Jarmużek, Dorota; Tartaro Bujak, Ivana; Pluskota-Karwatka, Donata; Ozdanovac, Luka; Džeba, Iva; Cindrić, Mario (2021) NanoUPLC-QTOF-MS/MS Determination of Major Rosuvastatin Degradation Products Generated by Gamma Radiation in Aqueous Solution. Pharmaceuticals, 14 (11). ISSN 1424-8247

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Rosuvastatin, a member of the statin family of drugs, is used to regulate high cholesterol levels in the human body. Moreover, rosuvastatin and other statins demonstrate a protective role against free radical-induced oxidative stress. Our research aimed to investigate the end-products of free radical-induced degradation of rosuvastatin. To induce the radical degradation, an aqueous solution of rosuvastatin was irradiated using different doses of gamma radiation (50–1000 Gy) under oxidative conditions. Rosuvastatin and related degradation products were separated on nanoC18 column under gradient elution, and identification was carried out on hyphenated nanoUPLC and nanoESI-QTOF mass spectrometer system. Elemental composition analysis using highly accurate mass measurements together with isotope fitting algorithm identified nine major degradation products. This is the first study of gamma radiation-induced degradation of rosuvastatin, where chemical structures, MS/MS fragmentation pathways and formation mechanisms of the resulting degradation products are detailly described. The presented results contribute to the understanding of the degradation pathway of rosuvastatin and possibly other statins under gamma radiation conditions.

Item Type: Article
Uncontrolled Keywords: rosuvastatin ; nanoLC-MS ; gamma radiation ; degradation products identification ; OH radical mechanisms
Subjects: NATURAL SCIENCES > Chemistry
Divisions: Division of Materials Chemistry
Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Qua/Qua Protein: Kvantitativna i kvalitativna analiza proteina za potrebe biomedicine i biotehnološke industrijeCindrić, MarioKK.
Depositing User: Amela Hozić
Date Deposited: 30 Dec 2021 12:40
DOI: 10.3390/ph14111160

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