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Leitmotif: protein motif scanning 2.0

Biđin, Siniša; Vujaklija, Ivan; Paradžik, Tina; Bielen, Ana; Vujaklija, Dušica (2020) Leitmotif: protein motif scanning 2.0. Bioinformatics, 36 (11). pp. 3566-3567. ISSN 1367-4803

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Motivation Motif-HMM (mHMM) scanning has been shown to possess unique advantages over standardly used sequence-profile search methods (e.g. HMMER, PSI-BLAST) since it is particularly well-suited to discriminate proteins with variations inside conserved motifs (e.g. family subtypes) or motifs lacking essential residues (false positives, e.g. pseudoenzymes). Results In order to make mHMM widely accessible to a broader scientific community, we developed Leitmotif, an mHMM web application with many parametrization options easily accessible through intuitive interface. Substantial improvement of performance (ROC scores) was obtained by using two novel parameters. To the best of our knowledge, Leitmotif is the only available mHMM application

Item Type: Article
Uncontrolled Keywords: Leitmotif server ; protein motif scanning
Subjects: NATURAL SCIENCES > Biology
Divisions: Division of Physical Chemistry
Project titleProject leaderProject codeProject type
Bioprospecting Jadranskog moraČož-Rakovac, Rozelinda; Dragović-Uzelac, Verica; Šantek, Božidar; Jokić, Stela; Jerković, Igor; Kraljević Pavelić, SandraKK.
Depositing User: Kristina Ciglar
Date Deposited: 08 Dec 2021 13:52
DOI: 10.1093/bioinformatics/btaa133

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