hrvatski jezikClear Cookie - decide language by browser settings

Anaphase B: Long-standing models meet new concepts

Vukušić, Kruno; Tolić, Iva M. (2021) Anaphase B: Long-standing models meet new concepts. Seminars in Cell & Developmental Biology, 117 . pp. 127-139. ISSN 10849521

PDF - Published Version - article
Available under License Creative Commons Attribution No Derivatives.

Download (7MB) | Preview


Mitotic cell divisions ensure stable transmission of genetic information from a mother to daughter cells in a series of generations. To ensure this crucial task is accomplished, the cell forms a bipolar structure called the mitotic spindle that divides sister chromatids to the opposite sides of the dividing mother cell. After successful establishment of stable attachments of microtubules to chromosomes and inspection of connections between them, at the heart of mitosis, the cell starts the process of segregation. This spectacular moment in the life of a cell is termed anaphase, and it involves two distinct processes: depolymerization of microtubules bound to chromosomes, which is also known as anaphase A, and elongation of the spindle or anaphase B. Both processes ensure physical separation of disjointed sister chromatids. In this chapter, we review the mechanisms of anaphase B spindle elongation primarily in mammalian systems, combining different pioneering ideas and concepts with more recent findings that shed new light on the force generation and regulation of biochemical modules operating during spindle elongation. Finally, we present a comprehensive model of spindle elongation that includes structural, biophysical, and molecular aspects of anaphase B.

Item Type: Article
Uncontrolled Keywords: anaphase B ; spindle elongation ; motor proteins ; microtubule sliding ; chromosome segregation ; microtubule pushing ; microtubule pulling
Subjects: NATURAL SCIENCES > Physics > Biophysics and Medical Physics
NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology
Divisions: Division of Molecular Biology
Project titleProject leaderProject codeProject type
Molecular origins of aneuploidies in healthy and diseased human tissues-ANEUPLOIDYIva Tolić; Nenad Pavin855158EK
Mehanizmi nastajanja snopova mikrotubula potrebni za sazrijevanje diobenog vretena-SpindleFormIva TolićPZS-2019-02-7653HRZZ
Inovativni protokoli mikroskopije za interdisciplinarna istraživanja u biomedicini-IPStedIva TolićKK.
Provedba vrhunskih istraživanja u sklopu Znanstvenog centra izvrsnosti za kvantne i kompleksne sustave te reprezentacije Liejevih algebri-QuantiXLieHrvoje Buljan; Pavle PandžićKK.
A new class of microtubules in the spindle exerting forces on kinetochores-NewSpindleForceIva Tolić647077EK
Depositing User: Maša Sabo
Date Deposited: 07 Sep 2021 13:52
DOI: 10.1016/j.semcdb.2021.03.023

Actions (login required)

View Item View Item


Downloads per month over past year

Increase Font
Decrease Font
Dyslexic Font