hrvatski jezikClear Cookie - decide language by browser settings

Fate and transformation of silver nanoparticles in different biological conditions

(COSTAction CA 17140) Pem, Barbara; Ćurlin, Marija; Domazet Jurašin, Darija; Vrček, Valerije; Barbir, Rinea; Micek, Vedran; Fratila, Raluca M.; de la Fuente, Jesus M.; Vinković Vrček, Ivana (2021) Fate and transformation of silver nanoparticles in different biological conditions. Beilstein journal of nanotechnology, 12 . pp. 665-679. ISSN 2190-4286

[img]
Preview
PDF - Published Version - article
Available under License Creative Commons Attribution.

Download (3MB) | Preview

Abstract

The exploitation of silver nanoparticles (AgNPs) in biomedicine represents more than one third of their overall application. Despite their wide use and significant amount of scientific data on their effects on biological systems, detailed insight into their in vivo fate is still lacking. This study aimed to elucidate the biotransformation patterns of AgNPs following oral administration. Colloidal stability, biochemical transformation, dissolution, and degradation behaviour of different types of AgNPs were evaluated in systems modelled to represent biological environments relevant for oral administration, as well as in cell culture media and tissue compartments obtained from animal models. A multimethod approach was employed by implementing light scattering (dynamic and electrophoretic) techniques, spectroscopy (UV–vis, atomic absorption, nuclear magnetic resonance) and transmission electron microscopy. The obtained results demonstrated that AgNPs may transform very quickly during their journey through different biological conditions. They are able to degrade to an ionic form and again reconstruct to a nanoparticulate form, depending on the biological environment determined by specific body compartments. As suggested for other inorganic nanoparticles by other research groups, AgNPs fail to preserve their specific integrity in in vivo settings.

Item Type: Article
Uncontrolled Keywords: animal tissue ; biological media ; nanoparticle aggregation ; nanoparticle dissolution ; nanoparticle reformation ; silver nanoparticles
Subjects: BIOMEDICINE AND HEALTHCARE > Pharmacy
Divisions: Division of Physical Chemistry
Projects:
Project titleProject leaderProject codeProject type
Značaj interakcija metalnih nanočestica sa sumpornim biomolekulama za nano-bio sučeljeVinković Vrček, IvanaIP-2016-06-2436HRZZ
Depositing User: Darija Jurašin
Date Deposited: 03 Aug 2021 10:23
Last Modified: 03 Aug 2021 10:24
URI: http://fulir.irb.hr/id/eprint/6502
DOI: 10.3762/bjnano.12.53

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

Contrast
Increase Font
Decrease Font
Dyslexic Font
Accessibility