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Salivary melatonin in oral squamous cell carcinoma patients

Salarić, Ivan; Karmelić, Ivana; Lovrić, Jasna; Baždarić, Ksenija; Rožman, Marko; Čvrljević, Igor; Zajc, Ivan; Brajdić, Davor; Macan, Darko (2021) Salivary melatonin in oral squamous cell carcinoma patients. Scientific reports, 11 . ISSN 2045-2322

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Abstract

Melatonin’s role in circadian rhythm is well documented, as are its’ anti-oxidant, oncostatic and antiinflammatory properties. Poor sleep quality has been associated as a potential risk factor for several malignancies, including head and neck cancers. The purpose of this study is to determine salivary melatonin (MLT) levels in oral squamous cell carcinoma (OSCC) patients, compare the salivary MLT levels with those in healthy individuals and compare the salivary and serum levels in OSCC patients. Furthermore, the aim is to investigate the potential relationship between sleep quality and salivary MLT levels in OSCC patients. Unstimulated (UWS) and stimulated (SWS) whole saliva was sampled from patients with T1N0M0 and T2N0M0 OSCC (N = 34) and 33 sex and age matched healthy subjects. Serum samples were taken from 11 OSCC patients. Sleep quality was measured using Pittsburgh Sleep Quality Index (PSQI) questionnaire. Melatonin levels in UWS and SWS were significantly higher in the OSCC group. Sleep quality was significantly lower in patients with OSCC (P = 0.0001). ROC analysis was found to be significant (P < 0.001) in evaluating MLT concentration limit in diagnosing OSCC. The expected relationship between sleep quality and salivary MLT levels in OSCC patients was not observed. Our results suggest salivary MLT as a potential biomarker that might facilitate non- invasive detection of early stage OSCC.

Item Type: Article
Uncontrolled Keywords: Melatonin, Salivary ; Oral cancer ; Circadian rhythm ; Sleep quality
Subjects: BIOMEDICINE AND HEALTHCARE > Dental Medicine
Divisions: Division of Physical Chemistry
Projects:
Project titleProject leaderProject codeProject type
Izolacija, kvantifikacija i kinetika salivarnih Ap4A, SCCA i TROP2 kod pacijenata s oralnim karcinomom i potencijalno malignim poremećajimaMacan, DarkoIP-2014-09-9376HRZZ
Depositing User: Marko Rožman
Date Deposited: 29 Jun 2021 11:43
Last Modified: 29 Jun 2021 11:44
URI: http://fulir.irb.hr/id/eprint/6472
DOI: 10.1038/s41598-021-92649-3

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