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Precipitation at room temperature as a fast and versatile method for calcium phosphate/TiO2 nanocomposites synthesis

Erceg, Ina; Selmani, Atiđa; Gajović, Andreja; Radatović, Borna; Šegota, Suzana; Ćurlin, Marija; Strasser, Vida; Kontrec, Jasminka; Kralj, Damir; Maltar-Strmečki, Nadica; Barbir, Rinea; Pem, Barbara; Vinković Vrček, Ivana; Dutour Sikirić, Maja (2021) Precipitation at room temperature as a fast and versatile method for calcium phosphate/TiO2 nanocomposites synthesis. Nanomaterials, 11 (6). ISSN 2079-4991

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The constantly growing need for advanced bone regeneration materials has motivated the development of calcium phosphates (CaPs) composites with a different metal or metal-oxide nanomaterials and their economical and environmentally friendly production. Here, two procedures for the synthesis of CaPs composites with TiO2 nanoplates (TiNPl) and nanowires (TiNWs) were tested, with the immersion of TiO2 nanomaterials (TiNMs) in corrected simulated body fluid (c-SBF) and precipitation of CaP in the presence of TiNMs. The materials obtained were analyzed by powder X-ray diffraction, spectroscopic and microscopic techniques, Brunauer–Emmett–Teller surface area analysis, thermogravimetric analysis, dynamic and electrophoretic light scattering, and their hemocompatibility and ability to induce reactive oxygen species were evaluated. After 28 days of immersion in c-SBF, no significant CaP coating was formed on TiNMs. However, the composites with calcium-deficient apatite (CaDHA) were obtained after one hour in the spontaneous precipitation system. In the absence of TiNMs, CaDHA was also formed, indicating that control of the CaP phase formed can be accomplished by fine-tuning conditions in the precipitation system. Although the morphology and size of crystalline domains of CaDHA obtained on the different nanomaterials differed, no significant difference was detected in their local structure. Composites showed low reactive oxygen species (ROS) production and did not induce hemolysis. The results obtained indicate that precipitation is a suitable and fast method for the preparation of CaPs/TiNMs nanocomposites which shows great potential for biomedical applications.

Item Type: Article
Uncontrolled Keywords: calcium phosphates ; TiO2 nanoplates ; TiO2 nanowires ; precipitation ; simulated body fluid ; reactive oxygen species ; hemocompatibility
Subjects: NATURAL SCIENCES > Physics
NATURAL SCIENCES > Interdisciplinary Natural Sciences
Divisions: Division of Materials Chemistry
Division of Physical Chemistry
Project titleProject leaderProject codeProject type
Mehanizmi nastajanja kalcijevih fosfata na anorganskim nanomaterijalima. Biomimetski put priprave multifunkcionalnih kompozita za regeneraciju čvrstih tkivaDutour Sikirić, MajaIP-2018-01-1493HRZZ
Depositing User: Nadica Maltar Strmečki
Date Deposited: 16 Jun 2021 10:55
DOI: 10.3390/nano11061523

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