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Analysis of Multiple Mycotoxins in the Qatari Population and Their Relation to Markers of Oxidative Stress

Al-Jaal, Belqes; Latiff, Aishah; Salama, Sofia; Hussain, Huda Mohamed; Al-Thani, Noora Abdulaziz; Al-Naimi, Noor; Al-Qasmi, Noof; Horvatovich, Peter; Jaganjac, Morana (2021) Analysis of Multiple Mycotoxins in the Qatari Population and Their Relation to Markers of Oxidative Stress. Toxins, 13 (4). ISSN 2072-6651

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Abstract

Mycotoxins are naturally occurring food toxins worldwide that can cause serious health effects. The measurement of mycotoxin biomarkers in biological fluids is needed to assess individuals' exposure. The aim of this study was to investigate the incidence of mycotoxins in the Qatari population. Serum samples from 412 adults and urinary samples from 559 adults were analyzed for the presence of mycotoxin biomarkers. Multimycotoxin approaches have been applied, using liquid chromatography mass spectrometry methods. Samples were further analyzed for the oxidative stress markers and compared with regard to the incidence of mycotoxins. The presence of mycotoxins was identified in 37% of serum samples and in less than 20% of urine samples. It was found that 88% of positive of the samples were positive for only one mycotoxin, while 12% of positive samples had two or more mycotoxins. Trichothecenes and zearalenone metabolites were most commonly detected mycotoxins, followed by aflatoxins, roquefortine C and mycophenolic acid. The presence of mycotoxins was found to positively correlate with oxidative stress markers. The obtained results illustrate the importance of mycotoxin biomonitoring studies in humans and the need to elucidate the underlying mechanisms of mycotoxin-induced toxicity.

Item Type: Article
Uncontrolled Keywords: human biomonitoring ; mycotoxin exposure ; oxidative stress
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Molecular Medicine
Depositing User: Morana Jaganjac
Date Deposited: 31 May 2021 10:35
Last Modified: 31 May 2021 10:36
URI: http://fulir.irb.hr/id/eprint/6424
DOI: 10.3390/toxins13040267

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